This study aimed to evaluate the effect of letrozole plus misoprostol to terminate non-viable pregnancies in first trimester compared with the use of misoprostol alone.
Inducing abortion by drugs is an alternative for surgery intervention, which has economic benefits with lower side effects and its rate of success is 60 to 95%. Letrozole is also one of aromatase inhibitors, which is used to stimulate ovulation in infertile women suffering ovulatory dysfunction. This drug is one of the main drugs for inhibiting aromatase, with a relatively short 45-hour half life, which is active orally and inhibits aromatase enzyme reversibly. Misoprostol is a relatively safe drug and of its side effects it is possible to mention to gestational effects, feeling of warmth, and shivering. Severe side effects of misoprostol consumption are severe bleeding and endometritis, with less than 1% prevalence based on studies.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
400
Patients received 10 mg of Letrozole daily for three days, subsequently receiving 800 µg of Misoprostol every three hours via vaginal or sublingual routes.
Patients received only 800 µg of Misoprostol.
Sohag University
Sohag, Egypt
Incidence of bleeding
Incidence of bleeding was recorded.
Time frame: 7 days following the Misoprostol dose
Number of dosages of prostaglandins
Number of dosages of prostaglandins was recorded.
Time frame: 7 days following the Misoprostol dose
Duration required for abortion
Duration required for abortion was recorded.
Time frame: 7 days following the Misoprostol dose
Incidence of adverse effects
Incidence of adverse effects such as nausea, vomiting, gastric distress, headache, fever, and shivers were recorded.
Time frame: 7 days following the Misoprostol dose
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