The goal of this observational study is to learn whether changes in the internal jugular vein during anesthesia induction can help predict low blood pressure and kidney injury after surgery. The main questions it aims to answer are: 1. Can the internal jugular vein collapsibility index before anesthesia predict low blood pressure during induction? 2. Can the change in internal jugular vein collapsibility from before to just after anesthesia predict low blood pressure during surgery and acute kidney injury after surgery? Participants will have routine ultrasound scans of the neck before anesthesia and again shortly after they fall asleep for surgery. Researchers will also record blood pressure during surgery and measure kidney function after surgery using routine blood tests.
This is a single-center prospective observational study in adults undergoing major abdominal or visceral surgery under general anesthesia. The study is designed to see whether bedside ultrasound measurements of the internal jugular vein can help identify participants who are at risk of low blood pressure during anesthesia induction and acute kidney injury after surgery. Participants will have one ultrasound scan while awake before anesthesia and a second scan shortly after loss of consciousness following propofol induction. The researchers will calculate the internal jugular vein collapsibility index from both scans and determine the change between them. They will then compare these measurements with blood pressure changes during the induction period and with postoperative kidney function, which will be assessed using routine creatinine tests. The study includes adults age 18 years and older who are having elective or urgent non-emergency major abdominal or visceral surgery. Participants must receive propofol for anesthesia induction and must have blood pressure monitoring during surgery. People with emergency surgery, dialysis dependence, major anatomic problems that prevent ultrasound scanning of the neck, or other conditions that would make the ultrasound measurement invalid will not be included. The study does not change routine anesthesia care. The ultrasound scans and blood tests are added only for research purposes, and the results are intended to help predict risk rather than guide treatment during the study itself.
Study Type
OBSERVATIONAL
Enrollment
150
Point-of-care Internal jugular vein ultrasound performed before induction and immediately after propofol induction to measure vein diameter and collapsibility index.
County Emergency Clinical Hospital of Targu Mureș
Târgu Mureş, Mureș County, Romania
Post-induction hypotension
Incidence of mean arterial pressure below 65 mmHg for atleast one consecutive minute during propofol induction
Time frame: Periprocedural
Change in Internal Jugular Vein Collapsibility Index
Difference between pre-induction and immediate post-induction internal jugular vein collapsibility index measured by point-of-care ultrasound
Time frame: From pre-induction to immediate post-induction
Postoperative Acute Kidney Injury
Acute Kidney Injury defined according to KDIGO criteria based on postoperative serum creatinine measurements
Time frame: Postoperative days one to three
Cumulative Intra-operative Hypotension Burden
Total duration of mean arterial pressure threshold of 65 mmHg during the operative period
Time frame: Induction to End of Surgery
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