Feasibility, Usability, and Acceptability of Virtual Reality-Based Cognitive and Physical Rehabilitation in Individuals With Mild Cognitive Impairment

The University of Texas Health Science Center, Houston10 enrolled

Overview

The purpose of this study is to demonstrate feasibility, usability, and acceptability of virtual reality (VR)-based cognitive and physical rehabilitation, evaluate adherence, tolerability, and fidelity to the VR intervention and explore preliminary effectiveness of VR-based rehabilitation on cognitive, physical, and functional outcomes.

Study Type

INTERVENTIONAL

Allocation

Purpose

DEVICE_FEASIBILITY

Masking

NONE

Enrollment

Conditions

Mild Cognitive Impairment Subjective Cognitive Decline (SCD)

Interventions

Participants will complete 3 supervised virtual reality (VR) sessions per week for 6 weeks for a total of 18 sessions using either the Real System VR headset or the Oculus Quest 2 VR headset. Each session will last approximately 60 minutes, with time allocated for setup and brief symptom checks.

Eligibility

Sex: ALLMin age: 55 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Clinical diagnosis of MCI (MoCA 18-26) or self-reported subjective cognitive decline (SCD) * Capacity to provide informed consent * Able to provide own transportation to sessions * Speaks and understands English * Ambulatory Exclusion Criteria: * Uncontrolled seizures or epilepsy * Severe psychiatric illness or active suicidality * Inability to follow instructions or tolerate VR (severe motion sickness) * Cognitive impairment as a result of a known cause (e.g., dementia, stroke, Traumatic Brain Injury (TBI), medications, etc.) * Any condition that the research team determines would interfere with safe participation

Outcomes

Primary Outcomes

Feasibility as assessed by the recruitment rate

Time frame: from baseline to end of intervention (6 weeks)

Feasibility as assessed by the retention rate

Time frame: from baseline to end of intervention (6 weeks)

Feasibility as assessed by the session completion rate

Time frame: from baseline to end of intervention (6 weeks)

Usability as assessed by the System Usability Scale (SUS)

The System Usability Scale (SUS) is a validated 10-item questionnaire used to assess participants' perceived usability of the intervention. each rated on a 5-point Likert scale from 1 = Strongly Disagree, 2 = Disagree 3 = Neutral ,4 = Agree, 5 = Strongly Agree. Scores range from 0 to 100, with higher scores indicating greater usability.