Effectiveness and Safety of a Hydrating Gel Containing Polyvinyl Pyrrolidine, Algin and Hyaluronic Acid Applied After and Without Fractional CO₂ Laser Therapy

Inclusion Criteria: 1. Female participants aged 18-60 years. 2. Patients attending the Dermatology and Venereology Outpatient Clinic of Universitas Indonesia Hospital (RSUI) who will receive the hydrating gel either following fractional CO₂ laser treatment or without undergoing the fractional CO₂ laser procedure. 3. Patients who will undergo or have undergone a priming regimen with topical retinoic acid preparations at concentrations of at least 0.025%, 0.05%, or 0.1% for at least 2 weeks prior to fractional CO₂ laser treatment, or prior to study participation in the non-laser group. 4. Willing to participate in the study and have provided written informed consent after receiving adequate explanation regarding the study. Exclusion Criteria: 1. Pregnant, breastfeeding, or currently using oral contraceptives at the time of assessment. 2. History of systemic retinoid use within the past 3 months. 3. History of or current treatment for hormonal/endocrine disorders or other serious medical conditions. 4. Currently receiving immunosuppressive therapy. 5. Participants who are unable or unwilling to comply with the study protocol and treatment regimen.