Evaluate and compare the effects on female facial skin of oral placebo (Product A), N-acetylneuraminic acid (Product B), and ACAI-PLUS (Product C) after 28, 56, and 84 days under normal usage conditions.
Study Type
OBSERVATIONAL
Enrollment
83
Oral placebo once daily for 84 consecutive days
Oral N-acetylneuraminic acid, once daily, for 84 consecutive days
Oral ACAI-PLUS, once a day, for 84 consecutive days
COSderma China Laboratory (Wuhan, China)
Wuhan, Hubei, China
Skin clinical scores
Dermatologists use a 10-point scale (0-9) and Volume 2 of the Atlas of Skin Aging for visual/tactile assessment. (includes elasticity, firmness, crow's feet, under-eye wrinkles, facial sagging, skin tone radiance, moisturization)
Time frame: Day0、Day28、Day56、Day84
Self-assessment by subjects
Subjects self-rated using a 10-point scale (0-9). (includes skin beauty, visibility of wrinkles, skin tone evenness, radiance, firmness)
Time frame: Day0、Day28、Day56、Day84
Dermal echo parameters
Using Dermcup® high-frequency B-mode ultrasound scanning (25 MHz probe) to obtain dermal echo parameters
Time frame: Day0、Day28、Day56、Day84
Color and clarity of spots
Dermatologists use Pantone color cards to score the color and clarity of spots
Time frame: Day0、Day28、Day56、Day84
Wrinkles, skin tone uniformity, and spots
COSderma Photobench photography + Newtone software analysis to obtain information on wrinkles, skin tone uniformity, and spots
Time frame: Day0、Day28、Day56、Day84
Stratum corneum moisture index
Corneometer® CM825 capacitance measurement method to obtain Stratum corneum moisture index
Time frame: Day0、Day28、Day56、Day84
Biomechanical properties of the skin
DTM310 Diastron® torque meter obtains information on skin biomechanical properties
Time frame: Day0、Day28、Day56、Day84
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Freckle removal effect
Siascope V® spectrophotometric intradermal analysis obtains information on freckle removal effects
Time frame: Day0、Day28、Day56、Day84
Self-assessment of cosmetic quality and efficacy
By distributing 12 questionnaires to the subjects, self-assessment information on the quality and effectiveness of cosmetics was obtained. A four-point Likert scale was used (Agree, Somewhat Agree, Somewhat Disagree, Disagree), and the questionnaire content included: 1. Skin feels better; 2. Skin becomes fairer; 3. Pigmentation on the skin lightens or decreases; 4. Skin becomes radiant; 5. Skin becomes more elastic; 6. Skin is firmer than before; 7. Skin wrinkles and fine lines improve; 8. Skin becomes moisturized/hydrated; 9. Skin's oil-water balance is better; 10. Skin looks rejuvenated, full of energy; 11. Sleep improves after consumption; 12. Memory improves after consumption.
Time frame: Day28、Day56、Day84