This study aimed to compare the efficacy of misoprostol versus intravaginal Evening Primrose Oil capsule as a cervical ripening agent prior to operative hysteroscopy.
Hysteroscopy is an operative procedure in which the gynaecologist directly examines the uterine cavity using a small telescopic instrument (hysteroscope) inserted via the vagina and the cervix. Misoprostol is a synthetic Prostaglandins (PGE1) analogue that has been found to be a safe and inexpensive agent for cervical ripening. It is one of the most studied cervical ripening agents used prior to hysteroscopy. Evening primrose oil is derived from the seeds of the evening primrose (Oenothera biennis) plant. It is rich in the essential fatty acid gamma linolenic acid, a fatty acid that the body converts to a hormone like substance called prostaglandin E1.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
230
Patients received evening Primorose Oil.
Patients received Misoprostol.
Sohag University
Sohag, Egypt
Assessment of cervical Ripening
Cervical ripening assessed by the interval between insertion of Hegar dilators size 3 and size 10, and by the size of the first Hegar dilator requiring forceful insertion.
Time frame: During operative hysteroscopy (2 hours after vaginal administration of the study medication)
Cervical Bleeding
Occurrence of cervical bleeding during cervical entry was recorded.
Time frame: During operative hysteroscopy (2 hours after vaginal administration of the study medication)
False Passage Formation
Occurrence of false passage during cervical instrumentation was recorded.
Time frame: During operative hysteroscopy (2 hours after vaginal administration of the study medication)
Cervical Laceration
Occurrence of cervical laceration during cervical dilatation was recorded.
Time frame: During operative hysteroscopy (2 hours after vaginal administration of the study medication)
Incidence of drug-related adverse effects
Incidence of drug-related adverse effects such as the occurrence of nausea, vomiting, diarrhea, fever, and severe abdominal pain were recorded.
Time frame: Until completion of the procedure (Up to 2 hours)
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.