Clinical evaluation of a Dexpanthenol-medicated wound plaster on standardized superficial skin abrasions
By utilizing a standardized abrasion model (based on the Wigger-Alberti methodology), the study aims to quantify the superior clinical performance of the Plaster compared to a standard plaster (conventional dry) and dry healing (no plaster). This evidence is crucial to demonstrate that the presence of Dexpanthenol provides a significant clinical benefit in terms of healing speed and aesthetic quality of the repaired tissue.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
SINGLE
Enrollment
40
On the wound will be applied daily an hydrogel plaster with Dexpanthenol
On the wound will be daily applicated a standard plaster on the market
la U.O.C. Anestesia Rianimazione degli Ospedali Riuniti Padova Sud
Monselice, PD, Italy
Re-epithelialization Rate
Measured as the percentage of wound closure compared to baseline (T0) with standardized photography
Time frame: day 5 day 7 day 15
Kinetics of Wound Closure
Time to 50% re-epithelialization
Time frame: Day 5 day 7
Subject-Reported Pain
Pain during wear and upon plaster removal assessed via a 100-mm Visual Analogue Scale (VAS)
Time frame: day 5 day 7
Scar Quality Assessment
using the Vancouver Scar Scale (VSS) (scoring vascularity, pigmentation, pliability, and height)
Time frame: day 5 day 7 day 15
general usability
Assessment of the plaster adherence to the perilesional skin over the treatment period using a 5-Point Adhesion Score 0 (100%) to 4 (0% fallen)
Time frame: Day 1, day 5, day 7
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