CHARACTERIZATION OF THE OCULAR SURFACE MICROBIOME IN THE REGION OF EPIRUS AND MACEDONIA (GREECE)

N/AActive Not RecruitingNCT07643077

University of Ioannina45 enrolled

Overview

The effect of latanoprost with preservatives on the ocular surface microbiome

Evidence suggests that the ocular surface microbiome of patients using preserved glaucoma eye drops differs from that of healthy individuals. These microbial changes have been linked to both the glaucoma treatment itself and the presence of preservatives, particularly benzalkonium chloride (BAK), in the eye drops. However, existing studies have primarily assessed these differences by comparing treated glaucoma patients to healthy controls, rather than examining changes within the same individuals over time. The aim of this study is to evaluate how glaucoma medications containing the preservative benzalkonium chloride affect the ocular surface microbiome in the same patients before and after the initiation of therapy.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Glaucoma

Interventions

Latanoprost with preservatives (BAK) once per day for at least 6 months periodDRUG

Existing studies have primarily assessed these differences by comparing treated glaucoma patients to healthy controls, rather than examining changes within the same individuals over time.

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: Newly diagnosed treatment naive glaucoma patients or those with ocular hypertension Exclusion Criteria: * Patients' history of recent ocular surgery or trauma, * Patient with any type of conjunctivitis and ocular surface inflammation recent to the time of diagnosis * Patients using topical antibiotics * Contact lenses wearers * Patients in other chronic treatments with eye drops

Locations (1)

University Hospital of Ioannina

Ioannina, Epirus, Greece

Outcomes

Primary Outcomes

Change in ocular microbiome

Alpha and beta diversity before and at least 6 months after the treatment

Time frame: 6 months

Data from ClinicalTrials.gov

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