Cancer Lipidome Adaptation and Resculping Through Omega-3 PUFAs in Breast Tumors

Inclusion Criteria: * Patient must be ≥18 years of age. * Breast tumor ≥1 cm. * Not currently taking dietary supplements containing fish oil or omega-3 PUFAs. A diet containing fish meat is permitted. * Unilateral and/or bilateral diagnostic breast mammogram and/or ultrasound within 60 days of enrollment. If breast MRI is done per treating physician's discretion, at least one breast imaging modality should be within 60 days of enrollment. * Pathologically proven diagnosis of invasive breast cancer, clinical stage I-III (cT1c-T4, N0-N3, M0). * Concurrent (neoadjuvant) systemic anti-cancer therapy is planned, including but not limited to endocrine therapy, chemotherapy, anti-HER2 therapy, and immunotherapy. * Eastern Cooperative Oncology Group (ECOG) performance status 0 to 2. * Bilateral breast cancer and/or multifocal, multicentric disease is allowed. * Appropriate pretreatment evaluations for protocol entry, including no clinical evidence for distant metastases, based upon the following minimum diagnostic workup: history/physical examination, including breast exam (inspection and palpation of the breasts), within 30 days prior to study entry. * Patients with a prior history of breast cancer will be considered eligible. * Surgical candidacy as determined by the treating physician. * Patient must provide study-specific informed consent prior to study entry or have a legally authorized representative provide consent. Exclusion Criteria: * American Joint Committee on Cancer (AJCC) clinical M1 breast cancer (i.e., with distant metastasis). * Purely noninvasive breast cancer (i.e., ductal carcinoma in situ, lobular carcinoma in situ). * Medical, psychiatric, or other condition that would prevent the patient from receiving the protocol treatment or providing informed consent.