Mitochondrial Energy Metabolism in Burns

Arkansas Children's Hospital Research Institute125 enrolled

Overview

The goal of this observational study is to assess the impact of burn injury on cellular energetics in patients that have been admitted to the burn center at Arkansas Children's Hospital for burn care and require one or more procedures to clean, debride, and repair burn wounds will be eligible to participate in this study. During the study, we will collect the following information: * General background information such as date of birth, height, weight, and other basic information. * Medical information, such as: basic medical information, details of burn injury, vital signs on the day of surgery, medicines you take during your stay, and some clinical tests. * Blood, urine, and tissue during surgeries you have during your stay.

Study Type

OBSERVATIONAL

Enrollment

125

Conditions

Burn Injury

Eligibility

Sex: ALLMin age: 2 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Male or Female * Ages 2 years to 80 years * Requiring hospital admission for burn care * All races * All ethnicities Exclusion Criteria: * Age \< 2 years * Under 10 kg in body mass * Age \> 80 years * Active pregnancy * Unable to provide informed consent and no legal authorized representative present * Patient is considered moribund at the time of admission by the treating physician.

Locations (1)

Arkansas Children's Hospital

Outcomes

Primary Outcomes

Blood Bioenergetics

Peripheral Blood Mononuclear Cell (PBMC) respiration

Time frame: Through study completion, an average of 1 year

Secondary Outcomes

Blood metabolics signatures