This study is a prospective randomized trial examining the effect of tranexamic acid (TXA) and aminocaproic acid (ε-Ahx) with local anesthetics and thrombin in all electively created surgical wound beds in hand surgery to provide long term pain relief and decrease the use of postoperative narcotics. All surgical created wounds for any hand surgery will be treated in a randomized fashion with the following four arms: 1. Bupivacaine + lidocaine 2. Bupivacaine + lidocaine + thrombin 3. Bupivacaine + lidocaine + thrombin + tranexamic acid 4. Bupivacaine + lidocaine + thrombin + aminocaproic acid All are applied topically to surgical bed prior to closure of skin.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
SINGLE
Enrollment
40
5 ml of 0.25% bupivacaine
5 ml of 1% lidocaine
10000 units of thrombin
500 mg of tranexamic acid
1000 mg of aminocaproic acid
NYU Langone Health
New York, New York, United States
Pre-Operative Pain
Pain rated on a scale from 0 (no pain) to 10 (highest level of pain ever experienced).
Time frame: Baseline (Day of Surgery)
Post-Operative Pain
Pain rated on a scale from 0 (no pain) to 10 (highest level of pain ever experienced).
Time frame: Up to Day 14 Post-Operative
Number of Opioid Prescription Pills Used
Opioid prescriptions (Norco 5/325 mg) will be given to patients post operatively. Total number of pills taken up until post operative day 14 will be recorded by the patient.
Time frame: Up to Day 14 Post-Operative
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