Probiotic for Alleviating Functional Constipation in Adults

Inclusion Criteria: (1) Chinese adults aged 18-70 years who meet the Rome IV diagnostic criteria for chronic constipation (duration of at least 6 months, with less than three passing stools per week and/or Bristol Stool Scale types 1 and 2); (2) The patient rarely experiences diarrhea without using laxatives; (3) The criteria for irritable bowel syndrome were insufffcient ; (4) patients that could complete the study according to the requirements of the trial protocol; (5) participants (including male subjects) who have no family planning within 14 days prior to screening and voluntarily take effective contraceptive measures within 6 months after the end of the trial; (6) Patients capable of understanding the clinical study and willing to comply with the study requirements and procedures; (7) Subjects who have signed the informed consent form. Only those who meet all the above conditions can be selected for the study. \- Exclusion Criteria: 1. Use of probiotics, prebiotics, or antibiotics within two weeks prior to enrollment and throughout the intervention period; 2. Regular use of a high-fiber diet, as measured by the recommended food score (RFS); 3. Regular use of medications affecting bowel habits, such as irritable bowel syndrome, functional bloating, and functional diarrhea; 4. Currently have, or have had in the past 2 years, any gastrointestinal conditions such as: Crohn's disease, celiac disease, ulcerative colitis, malignant tumor of the colon; 5. Medical history of cardiovascular, liver, or renal diseases; alcoholics; 6. Hypersensitivity to probiotics or the ingredients used in this study; 7. Pregnancy or breastfeeding; 8. Participation in another clinical trial in the 3 months before enrollment. -