This research will compare a new type of functional MRI (fMRI) called naturalistic viewing (also called movie watching) to standard clinical fMRI techniques. Standard clinical fMRI currently uses multiple tasks such as reading and responding to words or sentences to determine which areas of the brain are responsible for language. Surgeons can use this information to help plan brain surgeries. This research will help determine if the movie-watching fMRI is equivalent or better than the standard task-based fMRI. If so, it could be useful for planning patients' surgeries in the future, without the need for multiple tasks.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
90
Functional magnetic resonance imaging (fMRI) is a type of non-invasive imaging that measures blood oxygen level-dependent (BOLD) signal changes in the brain when a task is performed (such as reading) or BOLD signal changes during resting or watching naturalistic stimuli (such as movie clips).
Neuropsychological assessments are standardized tests used to evaluate cognitive, behavioral, and emotional functions that reflect the performance of different brain systems. These tests can be on paper or on a computer.
Brigham and Women's Hospital
Boston, Massachusetts, United States
Language localization
Sensitivity and specificity based on the proportion of activation within and outside of language regions-of-interest (ROIs).
Time frame: From enrollment to up to 6 months after brain surgery.
Language lateralization
Laterality index (LI) based on proportion of activation in the left vs. right hemisphere in language regions-of-interest (ROIs).
Time frame: From enrollment to up to 6 months after brain surgery.
FMRI language activations concordance with language fiber tracts
Concordance with language fiber tracts identified by diffusion MRI in terms of the Euclidean distance between fMRI language activations and the tracts.
Time frame: From enrollment to up to 6 months after brain surgery.
Quality metrics based on electrocortical stimulation (ECS)
Sensitivity and specificity computed relative to ECS positive/negative areas.
Time frame: From enrollment to up to 6 months after brain surgery.
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