H. Pylori Infection and Metabolic Syndrome: A Retrospective Cross-Sectional Study

Nanjing First Hospital, Nanjing Medical University5,218 enrolled

Overview

This retrospective cross-sectional study evaluates the association between Helicobacter pylori infection and metabolic syndrome using health examination data from 5,218 adults at Nanjing First Hospital. Participants are divided into H. pylori-positive and negative groups based on urea breath test results. The primary outcome is metabolic syndrome prevalence (CDS 2020 criteria). Multivariable logistic regression will be used to assess the independent association, with subgroup analyses by age and sex.

Study Type

OBSERVATIONAL

Enrollment

5,218

Conditions

HELICOBACTER PYLORI INFECTIONS Metabolic Syndrome

Interventions

No intervention. This is an observational study.OTHER

No intervention. This is an observational study.

Medical Language ↔ Plain English

Inclusion Criteria: 1. Age ≥18 years 2. Completed annual health examination at Nanjing First Hospital Health Management Center between May 1, 2024 and May 1, 2025 3. Underwent 13C or 14C urea breath test for H. pylori status assessment 4. Complete data on the following measurements: height, weight, waist circumference, systolic blood pressure, diastolic blood pressure, fasting blood glucose, triglycerides, and high-density lipoprotein cholesterol 5. No missing data on key study variables Exclusion Criteria: 1. Missing key data on H. pylori test results (13C or 14C urea breath test) 2. Missing any of the following primary metabolic indicators: waist circumference, blood pressure (systolic/diastolic), fasting blood glucose, triglycerides, or HDL-cholesterol 3. Pregnancy or lactation 4. History of severe liver dysfunction 5. History of severe kidney dysfunction 6. History of malignancy

Outcomes

Primary Outcomes

Prevalence of Metabolic Syndrome

Metabolic syndrome is defined according to the Chinese Diabetes Society (CDS) 2020 criteria. Participants meeting three or more of the following five criteria are classified as having metabolic syndrome: (1) central obesity: waist circumference ≥90 cm in males or ≥85 cm in females; (2) hyperglycemia: fasting blood glucose ≥6.1 mmol/L or previously diagnosed diabetes on treatment; (3) hypertension: blood pressure ≥130/85 mmHg or previously diagnosed hypertension on treatment; (4) hypertriglyceridemia: fasting triglycerides ≥1.70 mmol/L; (5) low HDL-cholesterol: fasting HDL-cholesterol \<1.04 mmol/L.

Time frame: Baseline