Enteral Lipid Supplementation and Bronchoplumonary Dysplasia of Premature Infants

Classification of BPD

Classification of Jensen et al. (2019) proposed a revised definition of BPD based on a modification of the NICHD (2001) criteria, which classifies the severity of bronchopulmonary dysplasia at 36 weeks postmenstrual age according to the level of positive pressure respiratory support, rather than the use of supplemental oxygen. This classification is independent of the prior duration or current concentration of oxygen therapy and is defined as follows: no BPD (no respiratory support), Grade 1 (nasal cannula ≤2 L/min), Grade 2 (nasal cannula \>2 L/min or non-invasive ventilation), and Grade 3 (invasive mechanical ventilation).

Time frame: Up to 36th week of postmenstrual age

The presence of comorbidities such as retinopathy of prematurity, necrotizing enterocolitis, intraventricular haemorrhage, periventricular leukomalacia, patent ductus arteriosus, and late-onset sepsis

Time frame: Up to 40th week of postmenstrual age

Need of respiratory support

The number of days requiring respiratory support (mechanical ventilation, continuous positive airway pressure (CPAP), high flow nasal cannula 3L/min or oxygen therapy).

Time frame: Up to 40th week of postmenstrual age

Mean oxygen demand (FiO2) during respiratory support

Time frame: Up to 40th week of postmenstrual age

Mean tidal volume (ml/kg) during respiratory support