Study of Teprenone in the Treatment of Glucocorticoid-Induced Drug-Related Gastrointestinal Injury

Inclusion Criteria: 1. Age 18 to 70 years; 2. Patients diagnosed with systemic lupus erythematosus (SLE) meeting the 2019 EULAR/ACR classification criteria for SLE; 3. Receiving moderate to high doses of glucocorticoids (prednisone or its equivalent 30-60 mg , once daily); 4. Voluntarily participate in this study and sign the informed consent form. Exclusion Criteria: 1. Presence of other gastric mucosal lesions, such as active ulcers, active bleeding, gastric cancer, gastric polyps, etc.; 2. History of subtotal gastrectomy; 3. History of endoscopic treatments, such as Endoscopic Submucosal Dissection (ESD) or Endoscopic Mucosal Resection (EMR); 4. Significant psychiatric and behavioral abnormalities or mood disorders; 5. History of clinically significant diseases, including: Chronic congestive heart failure (NYHA Class IV); History of echocardiography-confirmed ejection fraction (EF) \< 30%; Myocardial infarction, acute coronary syndrome, viral myocarditis, or pulmonary embolism within 6 months; Coronary revascularization within 6 months; Severe arrhythmia requiring treatment with Class Ia or III antiarrhythmic drugs;History of sick sinus syndrome, Mobitz II and Complete Heart Block without a permanent pacemaker implanted; QTc interval≥480 ms on screening ECG; 6. Laboratory abnormalities at screening as follows: Total bilirubin \> 3 times ULN (Upper Limit of Normal); AST/ALT \> 3 times ULN; Estimated glomerular filtration rate (eGFR) \< 30 mL/min/1.73m²; 7. Currently receiving treatment (e.g., chemotherapy, radiotherapy, immunotherapy) for other malignancies; 8. Pregnant or lactating women; 9. Allergy or hypersensitivity to the study drug(s).