This research intends to analyze how a 12-week adjustment in lifestyle influences inflammatory cytokines and oxidative stress indicators in overweight individuals diagnosed with type 2 diabetes and moderate CKD
: 60 patients, mostly sedentary, aged 36-58 years, were diagnosed with stages 3 and 4 chronic kidney disease (eGFR 25 to 60 ml/min/1.73 m²) with concomitant type 2 diabetes and indicated body mass indexes (BMI) between 30 to 35 kg/m². The subjects were randomly assigned to two unique groups: Intervention group (Group A): Participants completed supervised aerobic treadmill exercises while sticking to a calorie-limited diet (1200 kcal/day) throughout a 12-week period. Control group (Group B): Participants received standard nephrology care without any alterations in lifestyle. In the initial phases, there was a detailed analysis of biomarkers which was later confirmed in a review conducted at the 12-week mark focusing on TNF-α, IL-6, sCRP, CD, MDA, GSH, GPx, and SOD.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
60
diet (1200 kcal/day)
Mona Mohamed Abdelkhalek
Cairo, Egypt
RECRUITINGMDA
malondialdehyde
Time frame: at baseline and after 12 WEEKS
GSH
Glutathione
Time frame: at baseline and after 12 WEEKS
GPx
Glutathione peroxidase
Time frame: at baseline and after 12 WEEKS
SOD
Superoxide dismutase
Time frame: at baseline and after 12 WEEKS
IL-6
Interleukin-6
Time frame: at baseline and after 12 WEEKS
TNF-α
tumor necrosis factor alpha
Time frame: at baseline and after 12 WEEKS
CRP
C-reactive protein
Time frame: at baseline and after 12 WEEKS
BMI
Body mass index
Time frame: at baseline and after 12 WEEKS
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