The primary objective of this study is to investigate the effects of a multidisciplinary intervention, including a targeted adapted physical activity program, on lipid oxidation during a walking exercise in women with overweight or obesity, with or without polycystic ovary syndrome. Specifically, the study aims to compare changes in lipid oxidation before and after the intervention between women with polycystic ovary syndrome and those without polycystic ovary syndrome. The secondary objectives are to assess the impact of polycystic ovary syndrome on several physiological and metabolic parameters in women with overweight or obesity. These include: (i) resting energy metabolism; (ii) resting blood pressure and heart rate; (iii) energy expenditure, energy cost, and heart rate during a walking exercise; (iv) body composition, glycemic and lipid profiles, and circulating levels of sex hormones and adipokines; (v) movement behaviors; and (vi) physical fitness. In addition, the effect of the multidisciplinary intervention, including the adapted physical activity program, will be evaluated on these same outcomes: (i) resting energy metabolism; (ii) resting blood pressure and heart rate; (iii) energy expenditure, energy cost, and heart rate during walking exercise; (iv) body composition, glycemic and lipid profiles, and concentrations of sex hormones and adipokines; (v) movement behaviors; and (vi) physical fitness, in women with overweight or obesity, with or without polycystic ovary syndrome.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
40
Participants will participate to adapted physical activity, supervised by a professional
CHU de Clermont-Ferrand
Clermont-Ferrand, France
Lipid oxidation during walking exercise
Time frame: Baseline and after 10 weeks of intervention
Energy expenditure at rest
Time frame: Baseline and after 10 weeks of intervention
Lipid oxidation at rest
Time frame: Baseline and after 10 weeks of intervention
Carbohydrate oxidation at rest
Time frame: Baseline and after 10 weeks of intervention
Systolic blood pressure at rest
Time frame: Baseline and after 10 weeks of intervention
Diastolic blood pressure at rest
Time frame: Baseline and after 10 weeks of intervention
Heart rate at rest
Time frame: Baseline and after 10 weeks of intervention
Energy expenditure during walking exercise
Time frame: Baseline and after 10 weeks of intervention
Energy cost of walking
Time frame: Baseline and after 10 weeks of intervention
Carbohydrate oxidation during walking exercise
Time frame: Baseline and after 10 weeks of intervention
Heart rate during walking exercise
Time frame: Baseline and after 10 weeks of intervention
Fat mass
Time frame: Baseline and after 10 weeks of intervention
Fat-free mass
Time frame: Baseline and after 10 weeks of intervention
Body hydration
Time frame: Baseline and after 10 weeks of intervention
Fasting glycemia
Time frame: Baseline and after 10 weeks of intervention
Fasting insulin concentrations
Time frame: Baseline and after 10 weeks of intervention
Fasting triglyceride concentrations
Time frame: Baseline and after 10 weeks of intervention
Fasting LDL cholesterol concentrations
Time frame: Baseline and after 10 weeks of intervention
Fasting HDL concentrations
Time frame: Baseline and after 10 weeks of intervention
Fasting total cholesterol concentrations
Time frame: Baseline and after 10 weeks of intervention
Fasting free-fatty acid concentrations
Time frame: Baseline and after 10 weeks of intervention
Follicle-stimulating hormone concentrations
Time frame: Baseline and after 10 weeks of intervention
Luteinizing hormone concentrations
Time frame: Baseline and after 10 weeks of intervention
Estrogen concentrations
Time frame: Baseline and after 10 weeks of intervention
Progesterone concentrations
Time frame: Baseline and after 10 weeks of intervention
Total testosterone concentrations
Time frame: Baseline and after 10 weeks of intervention
Free testosterone concentrations
Time frame: Baseline and after 10 weeks of intervention
Fasting leptin concentrations
Time frame: Baseline and after 10 weeks of intervention
Fasting adiponectin concentrations
Time frame: Baseline and after 10 weeks of intervention
Time spent in sedentary behaviors
Time frame: Baseline and after 10 weeks of intervention
Time spent in moderate-to-vigorous physical activity
Time frame: Baseline and after 10 weeks of intervention
Physical fitness-minute walking distance
Time frame: Baseline and after 10 weeks of intervention
Right hand grip strength
Time frame: Baseline and after 10 weeks of intervention
Left hand grip strength
Time frame: Baseline and after 10 weeks of intervention
Number of repetitions during the 30-seconde chair stand test
Time frame: Baseline and after 10 weeks of intervention
Herat rate at the end of the step test
Time frame: Baseline and after 10 weeks of intervention
Heart rate 1 minute after the end of the step test
Time frame: Baseline and after 10 weeks of intervention
Heart rate 2 minutes after the end of the step test
Time frame: Baseline and after 10 weeks of intervention
Heart rate 3 minutes at the end of the step test
Time frame: Baseline and after 10 weeks of intervention
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