Link Between ASCorbemia Level and Osteoporosis

N/ANot Yet RecruitingNCT07660484

Centre Hospitalier Universitaire de Nice40 enrolled

Overview

This monocentric observational study aims to evaluate the association between plasma vitamin C levels (ascorbemia) and the presence of osteoporotic vertebral fractures in patients with osteoporosis. Forty participants will be enrolled at the Rheumatology

1. . Patients in group A or B will be seen in consultation or admitted by one of the medical team members among the investigators. 2. . After signing the informed consent and checking the inclusion criteria, the blood sample will be taken by a member of the nursing team of the department. 3. . The collection tube will then be placed in an opaque cooler, refrigerated with ice, and transported to the university hospital's biochemistry lab (routine assay). 4. . Next, the collection of planned clinical and paraclinical data: * Diet and risk factors for vitamin C deficiency: * Demographic data - osteoporosis risk factors * Bone status 5. . Once all the data is collected, we will carry out the statistical analyses, then draft the article, and finally publish it.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Osteoporosis Vitamin C Deficiency Vertebral Fractures

Interventions

Plasma vitamin C assessmentDIAGNOSTIC_TEST

Blood sampling for measurement of plasma vitamin C concentration (ascorbemia) in patient of the study

Eligibility

Sex: ALLMin age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Men aged 50 yars or older ; * Postmenopausal women ; * Afilliated with a health insurance and system ; * Written informed consent obtained. * Group 1 : Clincal osteoporotic vertebral fracture confirmed by imaging within the previous month ; Followed in the Rheumatology department for management of vertebral fracture. * Group 2 : Densitometric osteoporosis (T-score ≤ -2.5) ; No history of severe osteoporotic fracture ; No history of clinical or morphometric vertebral fracture. Exclusion Criteria: * Legal protection measure (guardianship, curatorship); * inability to provide informed consent ; * refusal to participate ; * Vertebral fracture related to tumor, * infection, trauma or non osteoporotic causes ; * asymptomatic vertebral fracture discovered incidentally ; * Severe densitometric osteoporosis for group 2 ; * Previous severe osteoporotic fracture for group B.

Locations (1)

CHU de Nice

Nice, France, France

Outcomes

Primary Outcomes

Plasma vitamin C concentration

Comparison of plasma vitamin C concentration (ascorbemia, µmol/L) between patients with osteoporotic vertebral fractures and patients with osteoporosis without vertebral fracture.

Time frame: day 1

Secondary Outcomes

Association between plasma vitamin C level and number of vertebral fractures

Assessment of the relationship between plasma vitamin C concentration and the number of osteoporotic vertebral fractures

Time frame: day 1

Association between plasma vitamin C level and lumbar bone mineral density

Assessment of the relationship between plasma vitamin C concentration and lumbar spine bone mineral density measured by DXA.

Time frame: day 1

Central Contacts

Marie-charlotte Trojani, Doctor

CONTACT

0492034702 trojani.mc@chu-nice.fr

Data from ClinicalTrials.gov

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