The purpose of this study is to evaluate the efficacy, safety, and tolerability of elecoglipron compared with oral semaglutide in adults with T2DM and increased cardiovascular risk that is inadequately managed alone or on stable treatment with other background glucose-lowering medication(s).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
1,200
Elecoglipron is administered orally once daily.
Semaglutide is administered orally once daily.
Change from baseline in Hemoglobin A1c (HbA1c)
Time frame: Baseline to Week 52
Percent change from baseline to Week 52 in body weight
Time frame: Baseline to Week 52
Change from baseline to Week 52 in body weight (kg)
Time frame: Baseline to Week 52
Achieved ≥ 5% weight loss from baseline at Week 52 and achieved HbA1c < 7% (53 mmol/mol) at Week 52
Time frame: Baseline to Week 52
Achieved HbA1c ≤ 6.5% (48 mmol/mol) at Week 52
Time frame: Week 52
Achieved HbA1c < 7% (53 mmol/mol) at Week 52
Time frame: Week 52
Achieved ≥ 5% weight loss from baseline at Week 52
Time frame: Baseline to Week 52
Change from baseline to Week 52 in Systolic Blood Pressure (BP) and Diastolic BP
Time frame: Baseline to Week 52
AstraZeneca Clinical Study Information Center
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Birmingham, Alabama, United States
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Mesa, Arizona, United States
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Phoenix, Arizona, United States
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Covina, California, United States
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Encinitas, California, United States
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Garden Grove, California, United States
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Loma Linda, California, United States
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