This observational study aims to emulate a hypothetical pragmatic, multicenter, non-blinded clinical trial enrolling adult patients undergoing haploidentical hematopoietic stem cell transplantation (haplo-HSCT) with grafts derived from either cousin or sibiling donors. The main research question is whether cousin donor-derived haplo-HSCT is associated with inferior clinical outcomes relative to sibling donor-derived haplo-HSCT. Study participants consist of adult patients diagnosed with hematological malignancies who underwent cousin or sibiling haplo-HSCT between 2017 and 2024, and all eligible recipients will receive regular follow-up assessments.
Study Type
OBSERVATIONAL
Enrollment
1,000
The First Affiliated Hospital of Soochow University
Suzhou, Jiangsu, China
Overall survival
estimated overall survival at 2 year
Time frame: 2 years after transplantation
Graft-versus-host disease-free and relapse-free survival
estimated graft-versus-host disease-free and relapse-free survival at 2 year
Time frame: 2 years after transplantation
Cumulative incidence of acute graft-versus-host disease
estimated cumulative incidence of acute graft-versus-host disease at 180 day
Time frame: 180 days after transplantation
Cumulative incidence of chronic graft-versus-host disease
estimated cumulative incidence of chronic graft-versus-host disease at 2 year
Time frame: 2 years after transplantation
Cumulative incidence of relapse
estimated cumulative incidence of relapse at 2 year
Time frame: 2 years after transplantation
Non-relapse mortality
estimated non-relapse mortality at 2 year
Time frame: 2 years after transplantation
Cumulative incidence of grade III-IV acute graft-versus-host disease
estimated cumulative incidence of grade III-IV acute graft-versus-host disease at 180 day
Time frame: 180 days after transplantation
Cumulative incidence of extensive chronic graft-versus-host disease
estimated cumulative incidence of extensive chronic graft-versus-host disease at 2 year
Time frame: 2 years after transplantation
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.