Safety and Efficacy of Renal Denervation for Untreated Grade I Hypertension: a Pilot Study

Inclusion Criteria: 1. Male or female, aged 18 to 65 years inclusive 2. Hypertension duration longer than 3 months 3. Hypertensive subjects who have been stopped taking antihypertensive drugs continuously and stably for at least 4 weeks or who do not take antihypertensive drugs , with office systolic/diastolic blood pressure still ≥140/90 mmHg and \<160/100 mmHg, and 24-hour ambulatory mean systolic /diastolic pressure ≥130/80 mmHg and \<140/90 mmHg; 4. The subject or his/her legal representative fully understands the content of the informed consent form for this trial and voluntarily signs the written informed consent form. Exclusion Criteria: 1. Pregnant or breastfeeding, or planning pregnancy during the study. 2. Renal artery anatomy unsuitable for ablation (e.g., ≥50% stenosis, renal artery aneurysm, malformation, renal artery diameter \<3 mm, or treatable segment length \<20 mm). 3. Subjects with a solitary kidney, prior renal transplantation, or requiring dialysis or eGFR\<40mL/min/1.73m2。 4. Other secondary hypertension not related to kidney disease (such as primary aldosteronism, pheochromocytoma/paraganglioma, Cushing's syndrome, thyroid disease, aortic coarctation, monogenic hypertension, renovascular hypertension, etc.). 5. Allergic to contrast agents. 6. Major surgery or trauma within 1 month before enrollment; acute coronary syndrome within 6 months; or planned surgery or cardiovascular interventional therapy within the next 6 months. 7. Orthostatic hypotension. 8. Type 1 diabetes mellitus. 9. History of bleeding diathesis and haematological disorders or coagulopathy 10. History of thromboembolic event within 6 months. 11. History of stroke or transient ischemic attack (TIA) within 6 months. 12. Severe peripheral arterial disease or unstable abdominal aortic aneurysm. 13. Severe valvular heart disease or anticipated need for surgical valve replacement during the study period. NYHA Class III/IV heart failure at screening or hospitalization for exacerbation of chronic heart failure within the past six months. 14. History of ventricular fibrillation, polymorphic ventricular tachycardia within six months, or prior implantation of an implantable cardioverter-defibrillator (ICD) or pacemaker. 15. Concomitant severe diseases that may interfere with study participation or affect survival, such as malignancy or AIDS. 16. Acute or severe systemic infection. 17. Other conditions deemed unsuitable for participation by the investigator.