Colistin Versus Colistin Combined With Cefoperazone-sulbactam for Multiresistant Acinetobactor Baumannii Ventilator-associated Pneumonia Treatment

Shaheed Mohtarma Benazir Bhutto Institue of Trauma80 enrolled

Overview

This study aims to evaluate clinical outcomes of colistin versus colistin in combination with cefoperazone-sulbactam for patients with MDR-AB VAP treatment.

MDR-AB (multidrug-resistant Acinetobacter baumannii) has been an increasingly common cause of ventilator-associated pneumonia (VAP) in intensive care unit (ICU). Colistin remains the last available antibiotic choice. Unfortunately, colistin monotherapy is often inadequate for microbiologic eradication and a risk factor of nephrotoxicity and for heteroresistance.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Clinical Response Radiological Response

Interventions

colistin plus cefoperazone-sulbactam combination groupDRUG

Combination therapy

ColistinDRUG

Monotherapy

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with a diagnosis of VAP due to A. baumannii Exclusion Criteria: * patients who had polymicrobial VAP * Patients with pre-existing severe renal failure and/or abnormal liver function tests * Patients allergic to colistin or cefoperazone-sulbactam

Locations (1)

Shaheed Mohtarma Benazir Bhutto Institue of Trauma

Karachi, Pakistan

Outcomes

Primary Outcomes

Clinical response

Clinical response was defined as observable improvement in the patient's clinical signs/symptoms, including absence of fever (temp\<38ºC) for three consecutive days or more, and decreasing amount and purulence of tracheal secretions

Time frame: within one week

Secondary Outcomes

Radiological response

Radiological response was defined as improvement/resolution of pulmonary infiltrates, as noted on chest x-rays following treatment.

Time frame: within one week

Data from ClinicalTrials.gov

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