Perioperative Antibiotic Exposure and Postoperative Delirium in Older Adults Undergoing Elective Non-cardiac Surgery: A Single-center Prospective Cohort Study

Chinese PLA General Hospital4,711 enrolled

Overview

This study aimed to characterize the current patterns of perioperative prophylactic antibiotic use and to systematically evaluate the association between different antibiotic classes and the occurrence of POD, thereby providing clinically relevant safety evidence for perioperative antibiotic decision-making and delirium prevention strategies.

This prospective, observational, single-center cohort analysis was a substudy of the Perioperative Database of Chinese Elderly Patients (PDCEP) study.

Study Type

OBSERVATIONAL

Enrollment

4,711

Conditions

Delirium - Postoperative

Interventions

Perioperative antibiotics exposureDRUG

Antimicrobial exposure was defined as a record of antibiotic use prior to the occurrence of delirium. Antimicrobials were divided into five non-mutually exclusive groups: beta-lactams (subclasses: first- through fourth-generation cephalosporins, penicillins and carbapenems), nitroimidazoles, glycopeptides, fluoroquinolones, and others (subclasses: aminoglycosides, oxazolidinones, antifungals, lincosamides, macrolides, and fosfomycins).

Eligibility

Sex: ALLMin age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients over 65 years old * patients undergoing elective non-cardiac surgery Exclusion Criteria: * older adult patients who had history of psychotic disorders * history of neurological disease * conditions that would make assessments for delirium unreliable * preoperative infection * severe hepatic and renal dysfunction, minor and intermediate clean-incision surgery * missing data exceeding 5%, and no medication records

Locations (1)

Chinese PLA General Hospital, Beijing

Beijing, China

Outcomes

Primary Outcomes

Incidence of postoperative delirium

Evaluations are conducted twice a day.

Time frame: Participants will be followed for the duration of hospital stay, an expected average of 7 days.

Data from ClinicalTrials.gov

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