This study aims to find out how much adimanebart gets into the blood circulation of healthy adults. Researchers will measure the amount of adimanebart in blood over time to learn how it moves through the body. The drug's safety will also be assessed. The participants will be assigned to one of 3 parts of the study: part 1 investigates the absolute bioavailability; part 2 investigates the effect of different body weights on adimanebart in blood after subcutaneous (SC) dosing; part 3 investigates formulation adaptations. Participants will be in the study for approximately up to 24 weeks.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
52
Intravenous infusion of adimanebart IV
Subcutaneous administration of Adminanebart SC
Subcutaneous administration of Adminanebart SC
Subcutaneous administration of Adminanebart SC
Altasciences
Montreal, Canada
RECRUITINGAUC0-inf
AUC0-inf = area under the concentration-time curve from time 0 to infinity
Time frame: Up to 20 weeks
adimanebart SC PK parameter: Cmax
Cmax = maximum observed concentration
Time frame: Up to 20 weeks
Incidence of AEs, SAEs, and AEs leading to adimanebart discontinuation
AE = adverse event ; SAE = serious adverse event
Time frame: Up to 20 weeks
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