Systemic Isotretinoin Therapy and Eye

Demet Mutlu60 enrolled

Overview

The dermatologist created a treatment plan for participants diagnosed with acne using medications containing vitamin A. While this medication has many benefits for the skin, it also has various side effects affecting many other systems. One of the most important of these side effects is related to the eyes. Therefore, the dermatologist will refer participants to an eye clinic for eye exams before and at regular intervals after starting this medication. During these exams, the investigators will perform eye measurements, a dry eye test, and an eye CT scan (OCTA). This study will compare patients who are scheduled to start treatment with vitamin A-containing pills for acne treatment with patients who have started treatment and completed their sixth month. This will allow for the early detection of potential side effects associated with this medication.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Dry Eye Choroidal Thickness Retinal Vascularisation Acne Cystic

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Being over 18 years of age * Having been diagnosed with cystic acne Exclusion Criteria: * History of glaucoma or ocular hypertension * Prior ocular surgical interventions * Any diagnosed ophthalmic condition, * Refractive errors exceeding 1.00 diopter axial length outside the 22 mm to 24 mm range * Oongoing dry eye therapy * Any systemic/local disorder known to impact retinal or choroidal vascularite or thickness.

Outcomes

Primary Outcomes

Number of Participants with Treatment-Related Adverse Events as Assessed by CTCAE v4.0

In the participant group receiving treatment for through study completion, any statistically significant change in DVD, SVD, CVD values or Shirmer test scores in OCTA data will be considered a treatment-related side effect.

Time frame: From enrollment to the end of treatment at 24 weeks