The aim of this study is to assess treatment patterns, characteristics, and clinical outcomes among adults with metastatic castration-resistant prostate cancer (mCRPC) who have previously received ≥1 androgen receptor pathway inhibitor (ARPI), ≥1 taxane, and 177Lu-PSMA-617 in the United States (US) real-world clinical practice. This study will be conducted using data extracted from the PRECISION (PRostatE Cancer dISease observatION) data platform.
Study Type
OBSERVATIONAL
Enrollment
1,067
Novartis
East Hanover, New Jersey, United States
Number of Patients by Number of Lines of Therapy (LOTs) Between mCRPC Diagnosis and Index Date
The index date is the date of the last treatment administration of the latest of an ARPI, taxane, and 177Lu-PSMA-617.
Time frame: Baseline
Number of Patients by Number and Type of Prior Therapies Indicated for Advanced Prostate Cancer (PC)
Number of patients by number and type of prior ARPI, taxane, 177Lu-PSMA-617, and other therapies indicated for advanced PC.
Time frame: Baseline
Number of Patients by Number of Prostate-specific Membrane Antigen (PSMA) Scans
Time frame: Baseline up to approximately 5 years
Number of Patients by Timing of PSMA Scans
Timing of scans is categorized as pre-mCRPC diagnosis, post-mCRPC diagnosis but pre-index date, and post-index date. The index date is the date of the last treatment administration of the latest of an ARPI, taxane, and 177Lu-PSMA-617.
Time frame: Baseline up to approximately 5 years
Number of Patients by Number of Post-index LOTs
Time frame: Up to approximately 5 years
Number of Patients by Type of Therapy at Each Post-index LOT
Time frame: Up to approximately 5 years
Time From Index Date to Next Therapy Initiation
The index date is the date of the last treatment administration of the latest of an ARPI, taxane, and 177Lu-PSMA-617.
Time frame: Up to approximately 5 years
Number of Patients by Patient Characteristics
Patient characteristics include race, geographical region, insurance status, marital status, type of treatment center, comorbidities, Gleason score, disease stage at diagnosis, and prostate-specific antigen (PSA) level.
Time frame: Baseline
Age
Time frame: Baseline
Progression-free Survival (PFS) From Index Date
Time from the applicable index date until progression or death from any cause. The index date is the date of the last treatment administration of the latest of an ARPI, taxane, and 177Lu-PSMA-617.
Time frame: Up to approximately 5 years
PFS From Initiation of First Post-index Therapy, in Patients With ≥1 Post-index Therapy
Time from the initiation of first post-index therapy until progression or death from any cause.
Time frame: Up to approximately 5 years
Overall Survival (OS) From Index Date
Time from the applicable index date until death from any cause. The index date is the date of the last treatment administration of the latest of an ARPI, taxane, and 177Lu-PSMA-617.
Time frame: Up to approximately 5 years
OS From Initiation of First Post-index Therapy, in Those With ≥1 Post-index Therapy
Time from initiation of first post-index therapy until death from any cause.
Time frame: Up to approximately 5 years
Among Patients With ≥1 Post-index Therapy, Number of Patients With a Reduction in PSA Level
Reduction in PSA level categorized as follows: * ≥50% (PSA50) reduction in PSA level * ≥80% (PSA80) reduction in PSA level * ≥90% (PSA90) reduction in PSA level
Time frame: Up to approximately 5 years
Among Patients With ≥1 Post-index Therapy, Number of Patients With PSA <0.2 ng/mL on First Post-index Therapy
Time frame: Up to approximately 5 years
Novartis Pharmaceuticals
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