Numerous factors, both individual and environmental, can influence aging, an individual's health, and their functional status. However, the understanding of the combined impact of lifestyle-related exposures (e.g., physical activity, diet, sleep) (personal external exposome), exposures to pollutants (environmental external exposome), and their biological responses (internal exposome)-in other words, the impact of the "exposome" on healthy aging-remains limited, particularly in characterizing the molecular mechanisms associated with these interactions. Exposome approaches identifying key exposures and molecular mechanisms could lead to a better understanding of how the environment, interacting with health behaviors, can affect functional status. Thus, the objective of this study is i) to evaluate the links between the external exposome, the internal exposome and the health of older and aging individuals, and ii) to identify biological markers associated with a vulnerable health status in older and aging individuals.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
NONE
Enrollment
400
Visit 1: blood sample, questionnaires on the personal exposome (lifestyle habits (e.g., physical activity, diet, stress) and social characteristics and health status) \| ii) Outpatient assessment: wearing a silicone bracelet for 7 days to measure external environmental exposure to pollutants and quantify physical activity \| iii) Visit 2: 1-year follow-up of health status
CHU de Nice - Hopital de Cimiez
Nice, France
Frailty (health measure)
Frailty is assessed using the Groningen Frailty Indicator. The scale comprises 15 items. The total score ranges from 0 to 25, with a higher score being worse.
Time frame: at baseline and 12 months later
Functional and health status
Disease presence : : Presence (yes/no) of chronic disease
Time frame: at baseline and 1 year
Physical functional capacities (health measure)
Physical functional capacities are assessed using the Short Physical Performance Battery which assess balance, walking capacities and strength via a sit to stand test
Time frame: at baseline and at 12 months
Quality of life (health measure)
Quality of life is assessed using the SF-12 questionnaire. The scale comprises 12 items.
Time frame: at baseline and 12 months
Autonomy (health measure)
Autonomy is assessed using the WHOQOL-OLD-AUT questionnaire. The scale comprises 4 items. The total score ranges from 4 to 20, with a higher score being better.
Time frame: at baseline and 12 months
Comorbidity (health measure)
Comorbidity is assessed using the Charlson Index which counts the number of comorbidities. Higher score means greater number of comorbidities and therefore a poorer health.
Time frame: at baseline and 12 months
Pollutant metabolites (internal exposome/biological measure)
Presence in the blood metabolome of molecules directly associated with pollutants (initial or biotransformed compounds). This outcome will be obtained through a metabolomic analysis by very high-resolution mass spectrometry (consisting of the analysis of all small organic molecules (or metabolites)) performed on blood samples taken by a blood sampling.
Time frame: at baseline.
DNA and telomere damage (internal exposome/biological measure)
DNA damage will be obtained through epigenetic analysis by studying miRNAs.
Time frame: at baseline.
exposure to air pollutants (external environmental exposome measure)
characteristics in terms of air pollution of the living space (quantity of fine particulate matter (PM), ozone (O3), nitrogen dioxide (NO2), or sulfur dioxide (SO2))
Time frame: at baseline
exposure to pesticides, hydrocarbons, plastics, flame retardant pollutants (external environmental exposome measure)
the exposure will be obtained through a silicone bracelet worn for 7 days by the participant, which will allow the measure of all exposures in the person's daily life.
Time frame: at baseline
Smoking habits (external personal exposome measure)
smoking/non-smoking status identified via questionnaire.
Time frame: at baseline.
Alcohol habits (external personal exposome measure)
consumption volume identified via questionnaire.
Time frame: at baseline
Self-reported physical activity habits (external personal exposome measure)
volume of physical activity practice over a week identified via questionnaire.
Time frame: at baseline
Objective-measured physical activity habits (external personal exposome measure)
volume of physical activity practice over a week identified via actigraphy.
Time frame: at baseline
Socioeconomic characteristic (external personal exposome measure)
level of study identified via questionnaire.
Time frame: at baseline
Socioeconomic characteristic (external personal exposome measure)
socio-professional category identified via questionnaire.
Time frame: at baseline
Psychological health (external personal exposome measure)
anxiety assessed using the Hospital Anxiety and Depression Scale (HAD). The scale comprises 14 items. The total score ranges from 0 to 21, with a higher score being worse.
Time frame: at baseline
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