The goal of this clinical trial is to learn whether certain natural hormones - Glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-2, (GLP-2), and amylin - affect blood flow to the bones.
In this study, participants will attend four study visits. At each visit they will be given infusions with either one of these hormones (GIP, GLP-2, pramlintide (a drug that mimics the natural hormone amylin)) or a placebo infusion (salt water). At the same time, participants will undergo a PET/CT scan where they will be administered a bone tracer (sodium fluoride), to visualize bone blood flow and activity. Participants do not know whether they are given active hormone or placebo infusion.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Enrollment
15
Placebo infusion for comparison of active hormone
Study tool
Study tool
Rigshospitalet
Copenhagen, Denmark
Median Ki in the Femur
Kinetic modelling
Time frame: 90 minutes
Median Ki in the lumbar spine
Kinetic modelling
Time frame: 90 minutes
Ki in other bones.
Kinetic modelling
Time frame: 90 minutes
Bone perfusion (K1)
Kinetic modelling
Time frame: 90 minutes
Bone incorporation fraction (K3/K3+K2)
Kinetic modelling
Time frame: 90 minutes.
Mean difference in CTX
Bone turnover marker.
Time frame: 90 minutes.
Mean difference in P1NP
Bone turnover marker
Time frame: 90 minutes
Mean difference in PTH.
Bone turnover marker.
Time frame: 90 minutes.
Mean difference in GIP(1-42)
Time frame: 90 minutes.
Mean difference in GLP-2(1-33)
Time frame: 90 minutes.
Mean difference in pramlintide
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Study tool
Time frame: 90 minutes.
Mean difference in blood glucose
Time frame: 90 minutes.
Mean difference in C-peptide
Time frame: 90 minutes.