The CPR, Pre-hospital ECPR and Early Reperfusion Study: A Target Trial Emulation

N/AActive Not RecruitingNCT07679737

Australian and New Zealand Intensive Care Research Centre250 enrolled

Overview

CHEER4TTE is a target trial emulation, designed to simulate a randomised controlled trial by utilising data from pre-existing data sources. The aim is to determine whether prehospital ECPR for refractory out-of-hospital cardiac arrest improves the rate of survival to hospital discharge when compared to conventional cardiac arrest care.

Study Type

OBSERVATIONAL

Enrollment

250

Conditions

Out of Hospital Cardiac Arrest Extracorporeal Cardiopulmonary Resuscitation

Interventions

Extracorporeal cardiopulmonary resuscitationOTHER

The Intervention being evaluated is the initiation of extracorporeal cardiopulmonary resuscitation (ECPR) at the scene, in addition to conventional cardiac arrest care.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Witnessed cardiac arrest * Bystander CPR * Refractory cardiac arrest (failure to achieve sustained ROSC \>20 minutes) * Initial cardiac rhythm VF, VT or PEA * Within the hours of prehospital ECPR service operation Exclusion Criteria: * Initial cardiac rhythm asystole * ROSC with sustained recovery * Unable to reach the patient and commence cannulation within 45 minutes of onset of arrest * Evidence of/suspected end-stage disease: * severe disability impairing activities of daily living * end-stage organ disease - cardiac, liver, lung, renal * other life-limiting diseases, e.g. malignancy, terminal illness * advance health care directive * Time periods of advanced public health restrictions in Victoria and NSW due to COVID-19

Locations (1)

Monash University

Melbourne, Victoria, Australia

Outcomes

Primary Outcomes

Survival to hospital discharge

Time frame: From meeting full eligibility criteria until the date/time of death or hospital discharge, assessed up to 180 days

Secondary Outcomes

Low flow time

Time frame: time from onset of arrest to time of ECPR flow, or time of death

ICU length of stay

Time frame: From the date/time of ICU admission until the date/time of ICU discharge/death, assessed up to 180 days

Mechanical ventilation days

Time frame: From date/time of mechanical ventilation commencement until date/time of liberation from mechanical ventilation assessed up to 180 days

ECMO complications

Time frame: From the date/time of commencement of ECMO support until 1 week following the date/time of cessation of ECMO support

Rates of organ and tissue donation in non-survivors

Time frame: In the 48hours following date/time of death

Data from ClinicalTrials.gov

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