This randomized study compares patient pain and comfort during ultrasound-guided thyroid fine needle biopsy using 21-gauge versus 27-gauge needles. Patients with thyroid nodules were randomly assigned to one of two needle sizes. Pain intensity was measured immediately after the procedure using a 0-100 Visual Analog Scale. The study was conducted at İzmir Atatürk Training and Research Hospital between January 2024 and March 2024. The aim is to determine which needle size causes less pain and better patient comfort during the biopsy procedure.
This prospective, randomized, single-blind clinical trial compares 21-gauge and 27-gauge needles for ultrasound-guided fine-needle biopsy of thyroid nodules. Participants are randomly assigned in a 1:1 ratio. The study aims to evaluate whether needle gauge affects patient pain and biopsy performance. Detailed eligibility criteria, outcome measures, and statistical analyses are provided in their respective sections.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
DOUBLE
Enrollment
159
4\. Ultrasound-guided fine needle biopsy performed using a 21-gauge needle for thyroid nodule cytology
Ultrasound-guided fine needle biopsy performed using a 27-gauge needle for thyroid nodule cytology
İzmir Atatürk Training and Education Hospital
Izmir, Turkey (Türkiye)
Pain score immediately after biopsy
Pain intensity measured using 100-mm Visual Analog Scale immediately after completion of ultrasound-guided thyroid fine needle biopsy. Higher scores indicate worse pain
Time frame: In 5 minutes after the procedure
Diagnostic Adequacy Rate.
Percentage of biopsy specimens considered adequate for cytopathological evaluation according to the Bethesda System for Reporting Thyroid Cytopathology
Time frame: Time Frame: Within 14 days after biopsy
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