The TRAUMAP study will function as a brain tissue repository for biopsy specimens from patients with traumatic brain injury undergoing brain surgery for contusion removal.
The TRAUMAP study aims to investigate the molecular and cellular mechanisms underlying secondary brain injury following traumatic brain injury (TBI) through the analysis of surgically resected contused human brain tissue. Tissue specimens will be collected from adult patients undergoing neurosurgical removal of cerebral contusions as part of routine clinical care. No additional procedures will be performed for research purposes, and only tissue that would otherwise be discarded will be used. Brain tissue samples will undergo histological, biochemical, and molecular analyses to investigate pathways involved in neuroinflammation, cell death, neurodegeneration, and endogenous regenerative responses. Molecular findings will be correlated with clinical characteristics to improve the understanding of TBI pathophysiology, validate preclinical observations, and identify potential therapeutic targets for future neuroprotective and regenerative strategies.
Study Type
OBSERVATIONAL
Enrollment
500
Asst Papa Giovanni Xxiii
Bergamo, Italy
RECRUITINGFondazione IRCCS San Gerardo dei Tintori
Monza, Italy
RECRUITINGTissue Used for Future Research Studies
Tissue collected through the study will be stored and used in future approved research studies
Time frame: Time frame as clinically indicated, maximum 2 weeks after TBI
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.