Puborectalis Syndrome as a Phenotype of Dyssynergic Defecation in Chronic Constipation: a Comparative Study of Defecography,High-resolution Anorectal Manometry, and Pelvic Floor Ultrasound

Third Military Medical University164 enrolled

Overview

Patients with suspected DD who met the Rome IV criteria were divided into the DD group and other types of constipation groups. The differences between the two groups were analyzed to explore the precise diagnostic scheme for DD.

This study was conducted solely at the Army Specialized Medical Center and was a single-center, bidirectional cohort study. Patients with suspected dyssynergic defecation who visited the constipation specialty clinic of Daping Hospital were collected. After the patients signed the informed consent form, they were asked to fill out the questionnaire (general clinical data questionnaire, Wexner constipation rating scale, ODS rating scale, and constipation patient quality of life scale (PAC-QOL)). The baseline data of the patients (such as age, gender, symptoms, constipation scale scores, intestinal satisfaction scores, etc.) and the results of anorectal manometry, defecography, and perineal ultrasound were statistically analyzed. Patients meeting the Rome IV criteria were grouped through DFG, ARM, and pelvic floor ultrasound examination. The differences in clinical main symptoms, constipation scores, defecography, perineal ultrasound, etc. between the two groups were observed, and the roles and correlations of each parameter in diagnosis were analyzed.

Study Type

OBSERVATIONAL

Enrollment

164

Conditions

Dyssynergic Defecation Puborectalis Syndrome Impaired Rectal Evacuation

Interventions

Analysis of inter-group differencesOTHER

Analysis of inter-group differences

Eligibility

Sex: ALLMin age: 16 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Age ranges from 16 to 85 years old. 2. Constipation patients should meet the Rome Ⅳ criteria for chronic constipation (must include two or more of the following: ① At least 25% of bowel movements are strenuous; ② At least 25% of bowel movements are lumpy or hard stools; ③ At least 25% of bowel movements are accompanied by a sense of incomplete evacuation; ④ At least 25% of bowel movements are associated with a feeling of anorectal obstruction or blockage; ⑤ At least 25% of bowel movements require manual assistance; ⑥ Fewer than 3 bowel movements per week). The healthy volunteer group has no above - mentioned constipation symptoms. 3. Participants should be able to understand and complete relevant questionnaires. 4. Participants should be willing to follow the research protocol and sign the informed consent form. Exclusion Criteria: 1. Pregnant women and lactating women 2. Suffering from gastrointestinal and other malignant tumors 3. Suffering from diseases such as diabetes and Parkinson's disease 4. Currently participating in other clinical trials

Locations (1)

Army Medical Center (Daping Hospital)

Yuzhong, Chongqing Municipality, China

Outcomes

Primary Outcomes

Rectal emptying rate，（%）

Rectal emptying rate is defined as the reduction in rectal area from pre-evacuation to post-evacuation, expressed as a percentage of the pre-evacuation area, as assessed by defecography.