This study was planned on the basis of the hypothesis that 'food supplements containing collagen will support the clinical effectiveness of non-surgical periodontal therapy'. In this context, the aim of the study is to investigate the therapeutic efficacy of collagen-containing food supplement as a host modulation agent in the non-surgical periodontal treatment of individuals with stage 3-4 periodontitis in a clinical and biochemical manner in a comprehensive manner. Initial day: Anamnesis, diagnosis and index measurements 2 days later, collection of serum samples from the patient, oral hygiene training and straightening of the whole mouth root surface and cleaning of the whole mouth tooth surface The next day, full mouth scalling and root planing are closed with the second session and tablets are started. End of 2nd month: Periodontal index measurement and oral hygiene training Collecting serum and tissue samples 2 days later End of 6th month Periodontal index measurement and oral hygiene training Collecting serum and tissue samples 2 days later
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
DOUBLE
Enrollment
52
Collagen supplements will not be given in the placebo group.
placebo will be given.
Recep Tayyip Erdogan University
Rize, Rize Province, Turkey (Türkiye)
probing pocket depth
The distance between the gingival margin and the pocket base was measured in millimeters.
Time frame: baseline, 1st month and 3rd month
clinical attachment loss
The distance from the enamel-cementum junction to the pocket base was measured in millimeters.
Time frame: baseline, 1st month and 3th month
assessment of interleukin-1 beta levels
Serum interleukin-1 beta levels were measured biochemically.
Time frame: baseline, 1st month and 3th month
assessment of matrix metalloproteinase-8 (MMP-8) levels
Matrix metalloproteinase-8 (MMP-8) levels in gingival crevicular fluid were measured biochemically.
Time frame: baseline, 1st month and 3 th month
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