This prospective study aims to observe changes in renal function and related parameters in patients with essential hypertension and primary hypercholesterolemia receiving either the combination of fimasartan and atorvastatin or the combination of fimasartan, atorvastatin, and ezetimibe.
Study Type
OBSERVATIONAL
Enrollment
12,700
The proportion of patients with positive urine dipstick albuminuria
Time frame: Week 12
Change in UACR from baseline to Weeks 12 and 24
UACR is defined as the urine albumin-to-creatinine ratio
Time frame: Week 12, Week 24
Proportion of participants achieving a ≥30% reduction in UACR from baseline at Weeks 12 and 24
UACR is defined as the urine albumin-to-creatinine ratio
Time frame: Week 12, Week 24
Change in UPCR from baseline to Weeks 12 and 24
UPCR is defined as the urine protein-to-creatinine ratio
Time frame: Week 12, Week 24
Proportion of participants achieving a ≥30% reduction in UPCR from baseline at Weeks 12 and 24
UPCR is defined as the urine protein-to-creatinine ratio
Time frame: Week 12, Week 24
Change in eGFR from baseline to Weeks 12 and 24
eGFR is defined as the estimated glomerular filtration rate
Time frame: Week 12, Week 24
Proportion of participants with a ≥50% decline in eGFR from baseline at Weeks 12 and 24
eGFR is defined as the estimated glomerular filtration rate
Time frame: Week 12, Week 24
Change in blood pressure from baseline at Weeks 12 and 24
Time frame: Week 12, Week 24
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Proportion of participants achieving the target blood pressure at Weeks 12 and 24
Time frame: Week 12, Week 24
Change in lipid profile (TC, HDL-C, TG, and LDL-C) from baseline at Weeks 12 and 24
Lipid proflie was defined that Total cholesterol (TC); High-density lipoprotein cholesterol (HDL-C);Triglycerides (TG); Low-density lipoprotein cholesterol (LDL-C)
Time frame: Week 12, Week 24
Proportion of participants achieving the target LDL-C level at Weeks 12 and 24
Time frame: Week 12, Week 24
Proportion of participants achieving both the target blood pressure and target LDL-C level at Weeks 12 and 24
Time frame: Week 12, Week 24