To evaluate the potential usefulness of 18F-FPyCO/SMBT-1 positron emission tomography/computed tomography (PET/CT) for the diagnosis of primary and metastatic lesions in various MAO-B-related disease patients.
Subjects with various Tau-related disease patients underwent18F-FPyCO/SMBT-1 PET/CT either for an initial assessment or for recurrence detection. Lesions uptake was quantified by the maximum standard uptake value (SUVmax). The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy of 18F-FPyCO/SMBT-1 PET/CT were calculated.
Study Type
OBSERVATIONAL
Enrollment
200
Each subject receive a single intravenous injection of 18F-FPyCO/SMBT-1, and undergo PET/ CT or MRI imaging within the specificed time.
The First Affiliated Hospital of University of Science and Technology of China
Hefei, Anhui, China
RECRUITINGThe Affiliated Hospital of Qingdao University
Qingdao, Shandong, China
RECRUITINGTianjin Medical University General Hospital
Tianjin, Tian, China
RECRUITINGStandardized uptake value (SUV)
Standardized uptake value (SUV) of 18F-FPyCO/SMBT-1 for each target lesion of subject or suspected PD.
Time frame: 30 days
Diagnostic efficacy
The sensitivity, specificity and accuracy of MAO-B PET/CT were calculated
Time frame: 30 days
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