Chronic post-surgical pain (CPSP) remains a common complication after thoracic surgery and may significantly impair patients' quality of life. Although the widespread adoption of video-assisted thoracic surgery (VATS) has reduced surgical trauma and improved postoperative recovery, a substantial proportion of patients still develop persistent pain. The EVATHO study is a multicenter prospective observational cohort designed to determine the prevalence of CPSP three months after VATS and to identify perioperative factors associated with its development. Adult patients undergoing thoracic surgery by VATS at Montpellier and Nice University Hospitals will be prospectively enrolled. Pain intensity, neuropathic pain characteristics, anxiety, depression, quality of life, and analgesic consumption will be assessed using validated questionnaires during the perioperative period and at 1 and 3 months after surgery. The results of this study may help identify patients at increased risk of CPSP and improve perioperative pain management strategies following thoracic surgery.
Study Type
OBSERVATIONAL
Enrollment
400
Number of participants with chronic post-surgical pain
Chronic post-surgical pain defined as a Brief Pain Inventory (BPI) average pain score greater than 3 at the 3-month postoperative follow-up.
Time frame: 3 months after surgery.
Postoperative pain at 1 month after VATS
Post-surgical pain defined as a Brief Pain Inventory (BPI) average pain score greater than 3 at the 1-month postoperative follow-up.
Time frame: 1 month after thoracic surgery
Visual Analogue Scale (VAS) pain score
Pain intensity measured using the Visual Analogue Scale (VAS), with scores ranging from 0 (no pain) to 10 (worst imaginable pain).
Time frame: Preoperative assessment, postoperative day 1, postoperative day 2, 1 month, and 3 months after surgery.
Cumulative postoperative opioid consumption.
Total opioid consumption during the postoperative period as morphine milligram equivalents
Time frame: Postoperative day 1, postoperative day 2, 1 month, and 3 months after surgery.
Douleur Neuropathie 4 (DN4) score
Neuropathic pain measured using the Douleur Neuropathique 4 (DN4) questionnaire. Scores range from 0 to 10, with scores greater than or equal to 4 indicating neuropathic pain.
Time frame: Preoperative assessment, postoperative day 1, postoperative day 2, 1 month, and 3 months after surgery.
Hospitalier Anxiety and depression Scale (HADS) anxiety score
Anxiety measured using the hospital Anxiety and Depression Scale (HADS-A). Scores range from 0 to 21, with scores greater than or equal to 11 indicating clinically significant anxiety.
Time frame: Preoperative assessment, 1 month, and 3 months after surgery.
Hospital Anxiety and Depression Scale (HADS) depression score
Depression measured using the Hospital Anxiety and Depression Scale (HADS-D). Scores range from 0 to 21, with scores greater than or equal to 11 indicating clinically significant depression.
Time frame: Preoperative assessment, 1 month, and 3 months after surgery
Brief Pain Inventory (BPI) pain interference score
Pain interference with daily activities measured using the Brief Pain Inventory (BPI) interference subscale
Time frame: 1 month and 3 months after surgery.
Short Form-12 Physical component summary score
Physical health-related quality of life measured using the Physical Component Summary (PCS) score of the Short Form-12 (SF-12) questionnaire.
Time frame: Preoperative assessment, 1 month, and 3 months after surgery.
Short form-12 Mental Component Summary score
Mental health-related quality of life measured using the Mental Component Summary (MCS) score of the Short Form-12 (SF-12) questionnaire.
Time frame: Preoperative assessment, 1 month and 3 months after surgery
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