Ageing of the general population may be a risk factor for various complications, including sarcopenia. Sarcopenia is a progressive loss of muscle mass and muscle strength, leading to a decrease in functional capacities. It affects between 0.7% and 16% of European adults over 70 years of age (1). Recent studies suggest that the faecal microbiota may be altered with ageing but also according to sarcopenic status. Furthermore, no study has currently published data on the relationship between salivary microbiota and sarcopenic status. The main hypothesis of this study is that a decrease in salivary microbiota richness could be associated with impaired handgrip strength in the ageing subject.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
60
Collection of saliva and stool samples for microbiota analysis and assessment of handgrip strength in adults aged over 70 years.
Rouen University Hospital
Rouen, France
Salivary microbiota richness
Salivary microbiota richness (gene richness/alpha diversity) measured from saliva samples.
Time frame: baseline
Fecal microbiota diversity
Assessment of fecal microbiota diversity from stool samples and its association with maximal handgrip strength.
Time frame: 15 days
Title: Fecal microbiota richness
Assessment of fecal microbiota richness according to handgrip strength and sarcopenia status.
Time frame: 15 days
Salivary microbiota diversity
Assessment of salivary microbiota diversity from saliva samples and its association with maximal handgrip strength.
Time frame: 15 days
Fecal microbiota richness according to sarcopenia status
Comparison of fecal microbiota richness between participants with and without sarcopenia.
Time frame: 15 days
handgrip strength
Identification of microbiological and clinical factors associated with lower maximal handgrip strength.
Time frame: 15 days
Risk factors associated with low microbiota genomic diversity
Identification of factors associated with reduced microbial gene richness and diversity in saliva and stool samples.
Time frame: 15 days
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