Vibrotactile Stimulation for Parkinson's Disease

Early Phase 1CompletedNCT07687732

University of Colorado, Denver12 enrolled

Overview

Investigation on whether and how vibrotactile stimulation applied on the fingertips affects beta power in the subthalamic nucleus.

With a randomized order, two stimulation patterns are applied for one hour each on the fingertips of Parkinson's patients with deep brain stimulation, while periodically recording from subthalamic nucleus (STN) local field potentials (LFPs). The randomized vibrotactile stimulation (RVS) power is expected to reduce neuronal synchronization and LFP beta power. The All-on stimulation pattern is not expected to reduce neuronal synchronization and LFP beta power.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Enrollment

Conditions

PARKINSON DISEASE (Disorder)

Interventions

Vibrotactile stimulationDEVICE

Vibration patterns applied on the fingertips.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: * The population to be enrolled will be between 18 and 85 years of * Have a diagnosis of idiopathic Parkinson's disease, determined by a movement disorders neurologist at the CU Movement Disorders Center * Has undergone deep brain stimulation surgery at the University of Colorado hospital Exclusion Criteria: * have severe sensory abnormalities of the fingertips such as vibratory urticaria * Patients that cannot clearly communicate with staff and speak English * Patients that are on psychoactive or narcoleptic medications, medications that affect brain function or alter EEG recorded activity (i.e., anticonvulsants, ADHD, depression, or anxiety medication) * Participation in another drug, device, biologic, or intervention trial concurrently or within the preceding 30 days.

Locations (1)

CTRC Space, Health Sciences Building

Denver, Colorado, United States

Outcomes

Primary Outcomes

Beta band power

13-30 Hz frequency band

Time frame: At baseline (pre-intervention) and after 30 min of intervention

Secondary Outcomes

MDS-UPDRS Part III

Movement disorder assessment for Parkinson's disease motor symptoms of the upper extremity. The scale is from 0 to 4 for the items in the MDS-UPDRS Part III, where 0 represents normal function (and 4 is worse).

Time frame: At baseline (pre-intervention) and 1-hour of intervention

Data from ClinicalTrials.gov

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