Preoperative Performance Indicators, Preoxygenation and Oxygen Reserve Relationship

N/ANot Yet RecruitingNCT07688941

Ankara City Hospital Bilkent120 enrolled

Overview

The goal of this observational study is to evaluate the relationship between preoperative cardiopulmonary performance indicators and preoxygenation efficiency along with oxygen reserve depletion in patients scheduled for elective surgery under general anesthesia. The main questions it aims to answer are: What is the relationship between Hand Grip Strength (HGS) and the time taken for end-tidal oxygen (EtO\_2) to reach 90% during preoxygenation? What is the relationship between the 6-Minute Walk Test (6MWT) distance and the Oxygen Reserve Index (ORI) depletion time during the apnea period? Participants will be asked to perform the following tasks during their preoperative and intraoperative care: Complete a 6-Minute Walk Test (6MWT) to determine preoperative functional capacity. Perform a Hand Grip Strength (HGS) test using a calibrated hand dynamometer to measure muscle strength. Undergo standardized preoxygenation with 100% oxygen via a tight-fitting face mask in the operating room while end-tidal oxygen (EtO\_2) and Oxygen Reserve Index (ORI) levels are continuously monitored.

Study Type

OBSERVATIONAL

Enrollment

120

Conditions

Sarcopenia Handgrip Strength Test Preoxygenation

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: Patients aged \>18 years ASA physical status I-III Scheduled for elective surgery under general anesthesia Voluntary written informed consent to participate in the study Exclusion Criteria: Severe COPD (Chronic Obstructive Pulmonary Disease) or restrictive lung disease NYHA Class III-IV Heart Failure Neuromuscular diseases Upper extremity pathologies affecting hand function (preventing HGS measurement) Orthopedic or neurological conditions preventing the 6-minute walk test (6MWT) Emergency surgeries

Outcomes

Primary Outcomes

Preoxygenation Efficiency (EtO_2 Time)

The time taken for end-tidal oxygen (EtO\_2) to reach 90% during preoxygenation.

Time frame: From the initiation of preoxygenation (0 seconds) until the EtO_2 values reach 90% (typically within 3 to 5 minutes before anesthesia induction)

Oxygen Reserve Depletion Time (ORI Time)

The time duration for the Oxygen Reserve Index (ORI) value to drop below 0.55.

Time frame: From the cessation of preoxygenation/initiation of apnea until the ORI drops below 0.55

Secondary Outcomes

Preoperative Functional Capacity (6MWT)

Total functional distance walked during the 6-minute walk test

Time frame: Preoperative period

Preoperative Muscle Strength (HGS)

Muscle strength measured using a calibrated hand dynamometer (the highest value of three consecutive measurements using the dominant hand)