Alzheimer's disease (AD) is the most common neurodegenerative disorder, characterized primarily by cognitive impairment as its main clinical symptom, often accompanied by emotional disturbances such as depression and anxiety, imposing a significant disease burden. Temporal Interference Stimulation (TIS) is an emerging non-invasive electrical stimulation technique that precisely targets deep structures within the hippocampus through interference of multiple electric fields. This study will administer a two-week TIS treatment to patients with AD co-occurring depression, targeting the hippocampus, and compare changes in patients' cognitive function, scores on depression and anxiety scales, and functional magnetic resonance imaging (fMRI) data before and after treatment. An emotional word recall task will be administered during fMRI scans. The aim of this study is to investigate the efficacy, safety, and neural mechanisms of TIS-mediated modulation of hippocampal circuits in improving cognitive and emotional functioning in patients with AD and comorbid depression.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
30
During the treatment period, all subjects were treated with a fixed time interference stimulation (TI) device at a frequency of 30 minutes twice a day, 5 days a week, for a total of 10 treatments. The output current intensity during treatment is Individualized.
Department of Psychiatry, First Affiliated Hospital of Zhejiang University
Hangzhou, Zhejiang, China
Alzheimer Disease Assessment Scale-Cognitive(ADAS-Cog)
The Alzheimer's Disease Assessment Scale-Cognitive (ADAS-Cog) is a brief, standardized, and widely used neuropsychological assessment designed to measure the severity of cognitive impairment, specifically the core symptoms of Alzheimer's disease (AD).Total Score Range:0 to 80. The higher scores mean a worse outcome.
Time frame: From enrollment to the end of treatment at 2 weeks
The 24-item Hamilton Depression Scale (HAMD-24)
The 24-item Hamilton Depression Scale (HAMD-24) is one of the most widely used clinician-administered questionnaires in psychiatry to assess the severity of depression.The total score ranges from 0 to 76, and higher scores mean a worse outcome.
Time frame: From enrollment to the end of treatment at 2 weeks
Mini-Mental State Examination (MMSE)
The Mini-Mental State Examination (MMSE) is a brief, 30-point questionnaire used to screen for cognitive impairment. The total score ranges from 0 to 30, and higher scores mean a better outcome.
Time frame: From enrollment to the end of treatment at 2 weeks
Clinical Dementia Rating (CDR)
The Clinical Dementia Rating (CDR) is a widely used numerical scale used to quantify the severity of symptoms of dementia. The total score ranges from 0 to 3, and higher scores mean a worse outcome.
Time frame: From enrollment to the end of treatment at 2 weeks
Hamilton anxiety scale (HAMA)
The Hamilton Anxiety Rating Scale (HAMA) is one of the first and most widely used clinician-rated scales designed to measure the severity of anxiety symptoms. The total score ranges from 0 to 56, and higher scores mean a worse outcome.
Time frame: From enrollment to the end of treatment at 2 weeks
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