Adropin Levels in Periodontal Disease

Giresun University60 enrolled

Overview

This study aimed to evaluate gingival crevicular fluid (GCF) and serum levels of Adropin and tumor necrosis factor (TNF)-alfa in patients with periodontitis before and after non-surgical periodontal therapy.

Thirty periodontitis and thirty periodontally healthy individuals were enrolled in the study. Clinical periodontal measurements were recorded; periodontitis patients received non-surgical periodontal treatment, and GCF and serum samples were collected at baseline and at 6 weeks after treatment. Adropin and TNF-alfa were determined by ELISA.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Periodontitis

Interventions

Nonsurgical periodontal therapyPROCEDURE

Nonsurgical periodontal therapy includes oral hygiene education and scaling and root planning approaches to eliminate microbial dental biofilm that is the primary etiology of periodontal diseases.

Eligibility

Sex: ALLMin age: 27 YearsMax age: 49 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * having at least 20 natural teeth, excluding third molars * having no systemic disease * non-smokers * Diagnosed with periodontally health and periodontitis patients Exclusion Criteria: * having any systemic diseases * smoking * current pregnancy or lactation * a history of periodontal treatment in the past 6 months * using antibiotic, anti-inflammatory drugs or any other drugs within the past 6 months.

Locations (1)

Giresun University

Giresun, Turkey (Türkiye)

Outcomes

Primary Outcomes

1. Adropin levels

Changes in Adropin levels before and after periodontal therapy

Time frame: Baseline and at 6 weeks after therapy

Secondary Outcomes

TNF-alfa levels

Changes in TNF-alfa levels before and after periodontal therapy

Time frame: baseline and at 6 weeks after therapy

Data from ClinicalTrials.gov

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