Different Treatment Options For Mature Teeth With Apical Periodontitis

Sara Tariq Elemam30 enrolled

Overview

A randomized control trial which aim to compare the healing potential for the following treatment options for mature teeth with apical periodontitis: Group I: Conventional root canal treatment (CRT) Group II: Regenerative endodontic treatment (RET) using a blood clot scaffold Group III: RET using a blood clot scaffold loaded with recombinant human BMPs (rhBMPs)

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Apical Periodontitis

Interventions

root canal treatment and intracanal medicamentPROCEDURE

conventional root canal treatment with obturation

RegenerationPROCEDURE

Regeneration using induction of bleeding

Regeneration with BMPsPROCEDURE

RET using a blood clot scaffold loaded with recombinant human BMPs (rhBMPs)

Eligibility

Sex: ALLMin age: 18 YearsMax age: 30 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients aged 18-30 years * Healthy patients with no systemic diseases or known allergic reactions * Mature permanent molars diagnosed with pulp necrosis * Presence of a medium sized periapical lesion confirmed clinically and radiographically (PAI=3,4,5) Exclusion Criteria: * Patients with generalized chronic periodontitis * Presence of small periapical lesions (PAI=1,2) * Periodontal pockets \> 3 mm * Presence of systemic diseases or known hypersensitivity to any material used in the study

Locations (1)

Faculty of dentistry ain shams university

Cairo, Egypt

Outcomes

Primary Outcomes

Healing in terms of volumetric change of lesion analyzed by CBCT

Time frame: 1 year

Data from ClinicalTrials.gov

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