Preoperative ROS1-TKI Therapy for ROS1 Fusion-Positive Locally Advanced Lung Adenocarcinoma

Peking University Cancer Hospital & Institute12 enrolled

Overview

This multicenter retrospective study evaluates preoperative ROS1-TKI therapy in patients with ROS1 fusion-positive locally advanced lung adenocarcinoma. Patients who received ROS1-TKI therapy before surgical resection were retrospectively identified from four tertiary hospitals in China. The study describes clinicopathological characteristics, radiographic response, treatment-related adverse events, surgical outcomes, pathological response, and follow-up outcomes.

Study Type

OBSERVATIONAL

Enrollment

Conditions

ROS1 Fusion-Positive Lung Adenocarcinoma

Interventions

ROS1-TKI TherapyDRUG

Preoperative ROS1 tyrosine kinase inhibitor therapy, including entrectinib or crizotinib, administered according to routine clinical practice before surgical resection.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Age 18 years or older. 2. Histologically confirmed lung adenocarcinoma. 3. ROS1 fusion positivity confirmed in tumor tissue at the DNA or RNA level. 4. M0 disease at baseline. 5. Receipt of targeted therapy before surgery. 6. Surgical resection performed after ROS1-TKI therapy. 7. Availability of comprehensive clinical, radiographic, treatment, surgical, pathological, and follow-up data. Exclusion Criteria: 1. Baseline M1 disease. 2. Receipt of radiotherapy or immunotherapy before ROS1-TKI therapy. 3. No surgical resection after ROS1-TKI therapy. 4. Lack of essential data for endpoint evaluation.

Locations (1)

Peking University Cancer Hospital & Institute, Beijing, Beijing 100142

Beijing, Beijing Municipality, China

Outcomes

Primary Outcomes

Major pathological response rate

Proportion of patients with 10% or fewer residual viable tumor cells in the resected primary tumor.

Time frame: At surgical resection

Data from ClinicalTrials.gov

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