Blood Flow Restriction and Aerobic Exercise in Iron Deficiency Anemia

N/ANot Yet RecruitingNCT07701213

Cairo University50 enrolled

Overview

Preventing iron deficiency anemia is essential for strengthening adolescent health and ensuring their full development. Strategies such as improving nutrition, expanding the availability of iron-fortified products, implementing pharmacological prevention, and raising awareness play a crucial role in addressing this issue.

Anemia is a global public health problem affecting both developing and developed countries at all ages, with major consequences for human health as well as social and economic burden. Iron deficiency affects more than 2 billion people world wide, and iron deficiency anemia (IDA) remains to be the top cause of anemia. For decades, blood flow restriction (BFR), originating from Japan, has become one of the most popular techniques in physiotherapy. To perform the BFR technique, a controlled tourniquet is performed, generating a gradual mechanical pressure just below it, affecting blood flow (both arterial and venous) and generating a hypoxia in the restricted area. For the realization of the tourniquet, mechanical cuffs are used, which are inflated and regulate the pressure generated in the compression zone, although nylon or elastic cuffs are also used for the realization of the tourniquet.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Iron Deficiency Anaemia

Interventions

aerobic exercise + blood flow restrictionDEVICE

Twenty five females will be subjected to supervised blood flow restriction combined with aerobic exercise program. participated in 3 months exercise training protocol, which included three walking training sessions per week on a treadmill set at a speed 3 km/h. They experienced 3 session/week and each session include 5-10 minutes .A pressure of between 140 and 200 mmHg was applied using a sphygmomanometer cuff placed at the thigh of the BFR group. The pressure of the cuff was increased until the participants adapted to the restriction stimulus during the early phase of training, and this pressure was maintained used during the training protocol. The strap pressure was increased by 10 mmHg per week, such that it reached 200 mmHg by the end of 12th week. The pressure on the thigh strap was abruptly released after five completions of the exercise set.

aerobic exercisePROCEDURE

participated in 3 months exercise training protocol, which included three walking training sessions per week on a treadmill set at a speed 3 km/h. They experienced 3 session/week and each session include 5-10 minutes warming up and five training sets (each lasting 2 min) with a 1 min rest period between each exercise session and ended with 5-10 minutes cooling down.

Eligibility

Sex: ALLMin age: 19 YearsMax age: 25 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Hb more than 8 and less than 12 in females. 2. Age: 19-25 year. 3. BMI ranging from 25 to 29.9 kg/m2. 4. No existing inflammatory conditions including rheumatoid arthritis disorders of the lower extremities. 5. Physical activity level less than 150 min per week Exclusion Criteria: 1. unstable hypertension, venous thromboembolism, hypercoagulable states, varicose veins, pregnancy, and hemophilia. 2. inherited or acquired red cell disorders (haemoglobinopathies). 3. acute or chronic infections (malaria, tuberculosis, HIV),. 4. severe anemia (Hb \<8 g/dL). 5. History of cardiovascular diseases. 6. Nutritional anemia (B12/folate) 7. Pregnancy. 8. Peripheral arterial disease. 9. Intermittent claudication. 10. Non smokers

Outcomes

Primary Outcomes

haemoglobin concentration

Time frame: Baseline and 12 weeks

Serum ferritin level

Time frame: Baseline and at 12 weeks

Haematocrit

Time frame: Baseline and at 12 weeks

Red blood cell (RBC) count