Effects of Blood Gas Perturbations

N/ANot Yet RecruitingNCT07701603

Swiss Federal Institute of Technology16 enrolled

Overview

In this study, the effects of blood gas perturbations on neuromuscular function of the diaphragm and lower limbs at rest and during exercise will be investigated.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Healthy

Interventions

Gas perturbationOTHER

Participants will be breathing a gas mixture of either room air, or hypoxia, or hypercapnia, or a combination of both during 2h. This is followed by an all-out breathing exercise test against a small resistance, while still being in the respective gas condition.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 55 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * healthy * non.smoking * normal lung function * BMI: 18.5-29.9 kg/m2 * willing to adhere to study rules Exclusion Criteria: * Acute illness or chronic conditions of the gastrointestinal tract, and health conditions affecting metabolism, the cardiovascular or the respiratory system, or sleep * Intake of medications affecting metabolism, the cardiovascular, the neuromuscular or the respiratory system, or sleep * Any metal or electronics inside of the body * Presence of cardiac pacemaker, implanted defibrillators or implanted neurostimulators * History of seizures or epilepsy * Tattoos on the stimulation sites * Previous enrolment in this study * For women: Pregnancy, breastfeeding, or intention to become pregnant during the study

Outcomes

Primary Outcomes

Diaphragm contractility

Diaphragm contractility measured before/during/following the gas exposures and the volitional respiratory muscle exercises using transdiaphragmatic and mouth pressure responses.

Time frame: Continuously measured from 10 sec before until 10 sec after each stimulation. One stimulation lasts for approx. 1 sec

Central Contacts

Christina M. Spengler, Prof.

CONTACT

+41 44 632 5007 christina.spengler@hest.ethz.ch

Data from ClinicalTrials.gov

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