NASA Exercise Prebreathe Study

Duke University30 enrolled

Overview

This study evaluates oxygen prebreathe protocols and exercise conditions to reduce risk of decompression sickness during simulated extravehicular activity. Healthy adult volunteers will undergo oxygen prebreathe followed by hypobaric chamber exposure with monitoring for symptoms and ultrasound detection of bubbles.

Study Type

INTERVENTIONAL

Allocation

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Decompression Sickness

Interventions

Oxygen Prebreathe and Hypobaric ExposurePROCEDURE

Prebreathe 100% oxygen followed by simulated spacewalk conditions in hypobaric chamber with exercise protocols.

Eligibility

Sex: ALLMin age: 30 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Non-smoking volunteers aged 30-60 years * Able to meet VO2 peak requirements (\>35 ml/kg/min males, \>30 ml/kg/min females) Exclusion Criteria: * Pregnancy * Lung disease, heart disease, hypertension, or diabetes * Musculoskeletal pain conditions * Requirement for regular medications such as analgesics

Locations (1)

Duke University Medical Center

Durham, North Carolina, United States

RECRUITING

Outcomes

Primary Outcomes

Number of participants with Decompression Sickness

Decompression sickness will be recorded during Extravehicular Activity (EVA) simulation at 6.2 psia following a one-hour oxygen prebreathe while resting, performing light exercise or heavier exercise.

Time frame: Up to 6 months

Data from ClinicalTrials.gov

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