This retrospective observational target-trial emulation uses electronic health record data from the TriNetX US Collaborative Network to compare preadmission glucose-lowering treatment strategies in adults with type 2 diabetes hospitalized with pneumonia. Time zero is the date of the index pneumonia admission. The study compares patients with evidence of prescriptions for both a GLP-1 receptor agonist and an SGLT2 inhibitor in the year before admission with patients prescribed a GLP-1 receptor agonist alone, an SGLT2 inhibitor alone, or usual care. Usual care includes metformin, sulfonylureas, or DPP-4 inhibitors without either study class. The primary outcome is a composite of all-cause death, invasive mechanical ventilation, or renal replacement therapy within 30 days of admission, with the individual components and 12-month mortality, major adverse cardiovascular events, and major adverse kidney events also evaluated. Propensity-score methods are used to reduce bias from nonrandom treatment selection.
Study Type
OBSERVATIONAL
Enrollment
71,775
Chung Shan Medical University Hospital
Taichung, Taichung, Taiwan
Composite outcome (all-cause mortality, invasive mechanical ventilation, or renal replacement therapy)
Time frame: Within 30 days after the index pneumonia admission
All-cause mortality
Time frame: Within 30 days after the index pneumonia admission
Invasive mechanical ventilation
Time frame: Within 30 days after the index pneumonia admission
Renal replacement therapy
Time frame: Within 30 days after the index pneumonia admission
Composite outcome (all-cause mortality, major adverse cardiovascular events, or major adverse kidney events)
Time frame: Through 12 months after the index pneumonia admission
All-cause mortality
Time frame: Through 12 months after the index pneumonia admission
Major adverse cardiovascular events
Time frame: Through 12 months after the index pneumonia admission
Major adverse kidney events
Time frame: Through 12 months after the index pneumonia admission
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