Acute Caffeine Intake in Older Adults

University of Alcala36 enrolled

Overview

Evidence regarding the ergogenic effects of caffeine is well-established in young adults, but evidence in older adults remains scarce, particularly during dynamic resistance exercise. Therefore, this study investigated the effects of acute caffeine ingestion on upper- and lower-body muscular strength and endurance performance, as well as the influence of sex and CYP1A2 genotype, in healthy resistance training-naïve older adults.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Caffeine Placebo - Control

Interventions

CaffeineDIETARY_SUPPLEMENT

Acute caffeine intake (3 mg/kg)

PlaceboDIETARY_SUPPLEMENT

Placebo (3 mg/kg maltodextrin)

Eligibility

Sex: ALLMin age: 55 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age ≥ 55 years. * Body mass index (BMI) lower than 25 kg/m². * Physically active subjects (≥150 min/week of moderate exercise). * Healthy men and women without neurological, cardiometabolic, immunological, or physical conditions that prevent them from performing physical exercise. * Participants capable of performing the tests. Exclusion Criteria: * History of neuromuscular, cardiac, or diseases that could affect liver or muscle metabolism. * Use of drugs or other stimulants that interfere with caffeine intake and intestinal absorption during the tests and study. * Body mass index (BMI) ≥ 25 kg/m². * Having undergone prolonged periods of forced physical inactivity during the 6 months prior to the study. • Performing strenuous exercise within 48 hours prior to the tests. * Failing to replicate the same food intake on the two experimental days. * Consuming caffeine after 6 PM on the day prior to training or testing.

Locations (1)

Facultad de Medicina y Ciencias de la Salud. Universidad de Alcalá

Alcalá de Henares, Madrid, Spain

Outcomes

Primary Outcomes

Mean velocity at different %1RM

Time frame: Through study completion, an average of 3 weeks

Number of repetitions performed during 1 set at 65%1RM until task failure

In bench press and back squat exercises

Time frame: Through study completion, an average of 3 weeks

Bar velocity deplacement performed in 1 set at 65%1RM until task failure

In bench press and back squat exercises

Time frame: Through study completion, an average of 3 weeks

handgrip and isometric mid-thigh pull tests

N generated

Time frame: Through study completion, an average of 3 week

Secondary Outcomes

CYP1A2 polymorphism

Using saliva sample and PCR

Time frame: Before the beginning of the trial

Mood state (tension, depression, anger, vigor, fatigue and confusion)

Participants graded a set of 29 items related to the mood on a Likert scale from 0 (not at all) to 4 (extremely) in reply to the question: How do you feel at this moment? to assess six scales: tension, depression, anger, vigor, fatigue and confusion.

Time frame: Through study completion, an average of 3 weeks

Adverse effects

perception of power, endurance, energy and exertion, as well as heart, muscular and gastrointestinal discomfort

Time frame: Through study completion, an average of 3 weeks

Data from ClinicalTrials.gov

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