A Study Exploring the Effect of Adjuvanted RZV or RSVPreF3 Vaccines on Coronary Plaque Progression in Adults >=50 Years of Age at Risk for Cardiovascular Events

Inclusion Criteria: * Participants, including participants with a caregiver who, in the opinion of the investigator, can and will comply with the requirements of the protocol. * Written or witnessed informed consent obtained from the participant prior to performance of any study-specific procedure. * Medically stable patients as established by medical history and clinical examination at screening. * Male or female participants \>=50 years of age (YOA) at the time of the first study intervention administration. * Participants with documented history of coronary artery calcium (CAC) and two or more risk factors for cardiovascular disease. * Participants with estimate glomerular filtration rate (eGFR) \>=45 mL/min/1.73m\^2. * Participants who can undergo serial CCTA. * Participants with no planned changes in medical therapies through the course of the study. * Participants of non-childbearing potential may be enrolled in the clinical study. * Participant of childbearing potential may be enrolled in the study if the participant: * has practiced adequate contraception for at least 30 days prior to study intervention administration, and * has a negative pregnancy test within 24 hours prior to the study intervention administration and prior to each CCTA, and * has agreed to continue adequate contraception during the entire duration of the study and for 8 weeks after completion of the study. Exclusion Criteria: Cardiovascular conditions * Prior atherosclerotic cardiovascular disease (ASCVD) event. * History or planned coronary artery bypass grafting (CABG), any cardiovascular surgery, percutaneous coronary intervention (PCI), or valvular intervention. * Heart failure with Class III or IV symptoms according to the New York Heart Association and/or unstable heart failure at the screening visit. Other medical conditions * History of any reaction or hypersensitivity likely to be exacerbated by any component of the study intervention(s). * Any confirmed or suspected immunosuppressive or immunodeficient condition, based on medical history and physical examination (no laboratory testing required). * Acute or unstable chronic conditions, clinically significant pulmonary, cardiovascular, hepatic, or renal functional abnormality, as determined by physical examination and/or laboratory screening tests. * Recurrent history or uncontrolled neurological disorders or any neuroinflammatory, congenital neurological conditions, encephalopathies, or seizures. * Any other clinical condition that, in the opinion of the investigator, might pose additional risk to the participant due to participation in the clinical study. * Condition that in the judgment of the investigator would make intramuscular injection unsafe. * Significant underlying illness that in the opinion of the investigator would be expected to prevent completion of the study. * History of malignancy \<=5 years, radiation therapy or systemic therapy prior to signing informed consent. * Any history of dementia or any medical condition that moderately or severely impairs cognition. Prior/Concomitant therapy * Previous vaccination against Herpes Zoster (HZ) (investigational or licensed vaccine) and/or planned administration of vaccination against HZ during the study period other than the vaccine administered during the study. * Previous vaccination with an RSV vaccine (investigational or licensed vaccine) and/or planned administration of an RSV vaccine during the study period other than the adjuvanted RSVPreF3 vaccine administered during the study. * Use of any investigational or non-registered product other than the study intervention(s) during the period beginning 30 days before the first dose of study intervention(s) (Day -29 to Day 1), or their planned use during the study period. * Administration of immunoglobulins or other blood products or plasma derivatives during the period starting 90 days before the study intervention or planned administration during the study period. * Chronic administration of immune-modifying drugs and/or planned use of long-acting immune-modifying treatments at any time up to the end of the study. * Planned administration/administration of a vaccine in the period starting 30 days before the first dose/each dose and ending 30 days after the last dose/each dose of study intervention(s) administration, with the exception of SARS-CoV-2 and inactivated seasonal influenza (flu) vaccine which can be administered up to 14 days before or 14 days after study intervention administration. Prior/Concurrent clinical study participation * Concurrently participating in another clinical study, at any time during the study period, in which the participant has been or will be exposed to an investigational or a non-investigational intervention drug/invasive medical device. * Contraindications to CCTA. Other exclusion criteria * Bedridden participants. * Pregnant or lactating participant. * History of current chronic alcohol consumption and/or drug abuse, based on investigator's judgment. * Any study personnel or their immediate dependents, family, or household members.